Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (06): 730-733. Previous Articles     Next Articles

Reports

红霉素9,11-亚胺醚和乙腈分子加合物的合成和晶体结构

史颖,姚国伟*,马敏   

  1. (北京理工大学生命科学与技术学院 北京100081)
  • 收稿日期:2004-03-22 修回日期:2004-12-20 发布日期:2005-05-30
  • 通讯作者: 姚国伟

Synthesis and Crystal Structure of Adducty of Erythromycin and

SHI Ying, YAO Guo-Wei* , MA Min   

  1. (School of Material Science and Engineering, Beijing Institute of Technology, Beijing 100081)
  • Received:2004-03-22 Revised:2004-12-20 Published:2005-05-30
  • Contact: YAO Guo-Wei

Erythromycin 9,11-iminoether, as a key intermediate, was obtained through controlling the condition of Beckmann rearrangement of erythromycin A (E) oxime. A stable molecular adduct can be formed from the title compound and acetonitrile with molar ratio of 1∶1. It is a transparent crystal characterized by monoclinic system and P21 space group. Contrasting the crystal structures between the title compound and erythromycin 6,9-iminoether reported in another paper, it would be useful to study the difference between the two isomers and the mechanism of Beckmann rearrangement and isomerization.

Key words: molecular adduct, erythromycin 9,11-iminoether, Beckmann rearrangement, crystal structure