Synthesis, Structure and Biological Activity of 1-(1-Methoxy-1-ferro-cenyl-3-arylpropan-2-yl)-1H-1,2,4-triazole Derivatives

Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (08): 972-976. Previous Articles Next Articles

Original Articles

1-(1-甲氧基-1-二茂铁基-3-芳基-丙烷-2-基)-1H-1,2,4-三唑类衍生物的合成及生物活性研究

金钟，刘伟，胡燕，刘建兵，邵玲，方建新*

(南开大学元素有机化学研究所元素有机化学国家重点实验室天津 300071)

收稿日期:2004-10-29 修回日期:2005-03-08 发布日期:2005-07-30
通讯作者: 方建新

Synthesis, Structure and Biological Activity of 1-(1-Methoxy-1-ferro-cenyl-3-arylpropan-2-yl)-1H-1,2,4-triazole Derivatives

JIN Zhong,LIU Wei,HU Yan,LIU Jian-Bing,SHAO Ling,FANG Jian-Xin*

(State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071)

Received:2004-10-29 Revised:2005-03-08 Published:2005-07-30
Contact: FANG Jian-Xin

Abstract

Eleven new 1-(1-methoxy-1-ferrocenyl-3-arylpropan-2-yl)-1H-1,2,4-triazole derivatives have been synthesized from acetylferrocene. The structures of the title compounds have been determined by elemental analysis, ¹H NMR and single crystal X-ray diffraction analysis. Bioassay showed that some of the title compounds had high plant-growth regulatory activity.

Key words: ferrocene, 1H-1,2,4-triazole, fungicidal activity, plant-growth regulatory activ-ity

Cite this article

JIN Zhong,LIU Wei,HU Yan,LIU Jian-Bing,SHAO Ling,FANG Jian-Xin*. Synthesis, Structure and Biological Activity of 1-(1-Methoxy-1-ferro-cenyl-3-arylpropan-2-yl)-1H-1,2,4-triazole Derivatives[J]. Chin. J. Org. Chem., 2005, 25(08): 972-976.

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1-(1-甲氧基-1-二茂铁基-3-芳基-丙烷-2-基)-1H-1,2,4-三唑类衍生物的合成及生物活性研究

Synthesis, Structure and Biological Activity of 1-(1-Methoxy-1-ferro-cenyl-3-arylpropan-2-yl)-1H-1,2,4-triazole Derivatives

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[1]	Penghui Li, Qingyang Xie, Fuxian Wan, Yuanhong Zhang, Lin Jiang. Synthesis and Fungicidal Activity of Novel Substituted Pyrimidine-5-carboxamides Bearing Cyclopropyl Moiety [J]. Chinese Journal of Organic Chemistry, 2024, 44(2): 650-656.
[2]	Min Liu, Dongyan Yang, Yumei Xiao, Wangcang Su, Fenghai Zhao, Qin Zhaohai .. Synthesis and Bioactivities of 5-Nitroimino-[1,4-2H]-1,2,4-triazolines as Olefin-Imidacloprid Mimics [J]. Chinese Journal of Organic Chemistry, 2023, 43(8): 2790-2799.
[3]	Xin Zuo, Shinuo Xu, Zhongyang Chen, Jianfeng Yan, Yaofeng Yuan. Research Progress of Electron Transport Properties in Ferrocene- Containing Single-Molecule Junctions [J]. Chinese Journal of Organic Chemistry, 2023, 43(7): 2313-2322.
[4]	Huan Xu, Hongfei Wu, Xiaoming Zhang, Xingxing Lu, Tengda Sun, Yue Qi, Yufan Lin, Xinling Yang, Li Zhang, Yun Ling. Design, Synthesis and Bioactivity of Sulfonyl Hydrazides and Hydrazides Containing Fragment 1,2,3,4-Tetrahydroisoquinoline [J]. Chinese Journal of Organic Chemistry, 2023, 43(2): 725-733.
[5]	Lei Wang, Shujing Yu, Na Yang, Baolei Wang. Studies on the Synthesis and Biological Activities of Novel Dihydroquinazolinone-Containing Caffeine Derivatives [J]. Chinese Journal of Organic Chemistry, 2023, 43(1): 299-307.
[6]	Changxing Sun, Fuhao Zhang, Huan Zhang, Penghui Li, Lin Jiang. Design, Synthesis, Fungicidal Activity and Molecular Docking Study of Novel 2-(1-Methyl-1H-pyrazol-4-yl)pyrimidine-4-carboxamides [J]. Chinese Journal of Organic Chemistry, 2023, 43(1): 229-235.
[7]	Qian Zhang, Yihao Li, Leichuan Xu, Haoyun Ma, Xiangdong Li, Ming'an Wang. Synthesis and Fungicidal Activity of Novel Butenolide Compounds Containing Oxime Ether Moiety [J]. Chinese Journal of Organic Chemistry, 2022, 42(8): 2438-2448.
[8]	Li Dai, Di Xu, Yifei Mao, Jiaqi Zhu, Mengjiao Yang. Structures and Synthetic Strategies of Chiral Oxazolinyl Ferrocene Derivatives [J]. Chinese Journal of Organic Chemistry, 2022, 42(8): 2364-2375.
[9]	Ze-Kun Wang, Zi-Yue Xu, Juan-Juan Li, Shang-Bo Yu, Hui Wang, Dong-Sheng Guo, Dan-Wei Zhang, Zhan-Ting Li. Gradient Enhancement of Supramolecular Organic Framework for Solubilization of Hydrophobic Molecules by Two Molecular Containers in Water [J]. Chinese Journal of Organic Chemistry, 2022, 42(7): 2236-2242.
[10]	Changkai Wang, Tengda Sun, Xuebo Zhang, Xinling Yang, Xingxing Lu, Huan Xu, Fasheng Shi, Li Zhang, Yun Ling. Design, Synthesis and Bioactivity of Novel Fluoropyrazole Hydrazides [J]. Chinese Journal of Organic Chemistry, 2022, 42(5): 1527-1536.
[11]	Weiwei Wang, Yihao Li, Xinlei Liu, Yu Zhao, Mingan Wang. Synthesis and Fungicidal Activity of Novel 3,7-Dimethylocta-2,6-dienamides and 3,7-Dimethyl-6,7-dihydroxyoct-2-enamides [J]. Chinese Journal of Organic Chemistry, 2021, 41(9): 3717-3725.
[12]	Hang Liu, Shuyun Zhang, Huan Li, Yan Zhang, Zhengming Li, Baolei Wang. Synthesis and Biological Activities of Novel 8-((3,4,4-Trifluorobut-3-en-1-yl)thio)-substituted Methylxanthines and Their Derivatives [J]. Chinese Journal of Organic Chemistry, 2021, 41(5): 2091-2098.
[13]	Can Jin, Xile Deng, Yong Zhou, Xiaomao Zhou. Design, Synthesis, Crystal Structure, and Fungicidal Activity of L-Carvone Derivatives Containing an Oxime Ester Moiety [J]. Chinese Journal of Organic Chemistry, 2021, 41(5): 2008-2018.
[14]	Wei Yu, Han Wang, Li-Jing Min, Xue-Wen Hua, Xing-Hai Liu. Synthesis and Fungicidal Activity of Novel Allyl Benzoate Compounds Containing Triazole [J]. Chinese Journal of Organic Chemistry, 2021, 41(2): 826-832.
[15]	Shuyun Zhang, Hang Liu, Lei Wang, Zhengming Li, Baolei Wang. Studies on the Synthesis, Structural Characterization and Biological Activities of Novel Caffeine Derivatives Containing Substituted-Piperazine Moiety [J]. Chinese Journal of Organic Chemistry, 2021, 41(10): 4075-4082.