Synthesis of N-Glycosyl-N'-6-substitutedchromon- 3-ylmethylideneaminothioureas

Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (9): 1121-1124. Previous Articles Next Articles

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N-糖基-N'-(6-取代色酮-3-基-亚甲氨基)硫脲类化合物的合成

吴鹏¹，曹玲华*^,1,2

(¹新疆大学化学化工学院乌鲁木齐 830046)
(²南开大学元素有机化学国家重点实验室天津 300071)

收稿日期:2004-10-15 修回日期:2005-03-28 发布日期:2005-08-24
通讯作者: 曹玲华

Synthesis of N-Glycosyl-N'-6-substitutedchromon- 3-ylmethylideneaminothioureas

WU Peng ¹,CAO Ling-Hua*^,1,2

(¹ College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046)
(² State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071)

Received:2004-10-15 Revised:2005-03-28 Published:2005-08-24
Contact: CAO Ling-Hua

Abstract

The glycosyl isothiocyanates 1a～1c reacted with anhydrous hydrazine gave N-glycosyl- N'-aminothioureas 2a～2c, which then reacted further with 6-substituted-3-formylchromones 3a～3d to give a series of new N-glycosyl-N-6-substitutedchromon-3-ylmethylideneaminothioureas 4a～4d, 5a～5d, 6a～6d. The structures of the new compounds were established on the basis of IR, ¹H NMR and MS data, and the derivatives of glycose kept the original β-configuration.

Key words: thiourea, glycosyl isothiocyanate, chromone

Cite this article

WU Peng ,CAO Ling-Hua*^,1,2. Synthesis of N-Glycosyl-N'-6-substitutedchromon- 3-ylmethylideneaminothioureas[J]. Chin. J. Org. Chem., 2005, 25(9): 1121-1124.

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N-糖基-N'-(6-取代色酮-3-基-亚甲氨基)硫脲类化合物的合成

Synthesis of N-Glycosyl-N'-6-substitutedchromon- 3-ylmethylideneaminothioureas

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