Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (8): 3242-3248.DOI: 10.6023/cjoc202102007 Previous Articles     Next Articles



杜科莹, 张展铭, 盛卫坚*()   

  1. 浙江工业大学化学工程学院 杭州 310014
  • 收稿日期:2021-02-01 修回日期:2021-03-16 发布日期:2021-05-08
  • 通讯作者: 盛卫坚

Copper-Catalyzed the Synthesis of 3-Trifluoromethylchromone via Trifluoromethyl Radical Addition Tandem Cyclization Reaction of 2-Hydroxyphenyl Enaminones

Keying Du, Zhanming Zhang, Weijian Sheng()   

  1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
  • Received:2021-02-01 Revised:2021-03-16 Published:2021-05-08
  • Contact: Weijian Sheng

Chromones have shown strong drug activity in anti-tumor, antibacterial and anti-inflammatory aspects for their unique skeleton structure. Using Cu(OAc)2 as catalyst, CF3SO2Na as trifluoromethyl radical source, tert-butanol peroxide (TBHP) as oxidant, 3-trifluoromethylchromone was synthesized by radical addition tandem cyclization reaction of 2-hydroxyphenyl enaminone under mild reaction conditions, and enaminone substrate has good functional tolerance.

Key words: radical addition, trifluoromethyl, enaminone, chromones