The formation of enantiopure optically active biomolecules is an important chapter in the history of evolution. "Absolute" asymmetric synthesis, i. e. an asymmetric synthesis carried out in a closed system without any external chiral inducing agents or with circularly polarized light, supports the explanations of how optical activity could have arisen under pre-biotic conditions. In the present review, we describe the asymmetric synthesis via the reactions of chiral crystals of achiral molecules.

Key words: CYCLOADDITION REACTION