The synthesis of 1,2- and 1,3-anhydro glycopyranose benzyl ethers ws successfully achieved via intramolecular SN2 reaction of the corresponding C-2 (or C-3 for 1,3-anhydro sugars) alkoxide with C-1 bearing chloride, and the synthesis of some 1,2-anhydro pyranoses by the intramolecular reaction of the corresponding C-1 alkoxide with C-2 bearing tosyloxy group (inverse ring closure). The synthesis of 1,2-anhydro glycofuranose benzyl ethers was carried out only by the inverse ring closure. Ring opening of the 1,2- and 1,3-anhydro sugars usually afforded 1,2-trans and 1,3-trans linked glycosides respectively. Conformational analysis of the 1,2- and 1,3-anhydro sugars was performed by ^1H NMR spectrometry and molecular mechanics calculations.

Key words: PROTON MAGNETIC RESONANCE SPECTROMETRY, CONFORMATION, FURANOSE, PYRANOSE