An improved Adler method for preparing 5,10,15,20-meso-tetra(4- aminophenyl)porphine (TAPPH~2) is presented. TAPPH~2 was synthesized by direct condensation of pyrrole with 4-aminobenzaldehyde in refluxing propanoic acid in the presence of vitamin C. This new synthetic strategy for preparing TAPPH~2 should greatly expand synthetic entries to porphines containing amino groups. As a complementary to the Adler procedure this methodology allows forpreparation of aminophenylporphines from sensitive aminobenzaldehydes in ca 20% yields without suffering from difficult purification problems.

Key words: CONDENSATION REACTION, PORPHINE P, BENZALDEHYDE P, VITAMIN C