Chin. J. Org. Chem. ›› 2006, Vol. 26 ›› Issue (02): 199-202. Previous Articles     Next Articles

Original Articles

新型氧化剂邻碘酰萘甲酸对甾体羟基选择性氧化的研究

苏熠东,郑云红,李援朝*   

  1. (中国科学院上海生命科学研究院上海药物研究所 上海 201203)
  • 收稿日期:2005-04-13 修回日期:2005-08-04 发布日期:2006-01-21
  • 通讯作者: 李援朝

Selective Oxidations of Steroidal Hydroxyl Groups with a Novel Oxidant o-Iodoxynaphthoic Acid

SU Yi-Dong,ZHENG Yun-Hong,LI Yuan-Chao*   

  1. (Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203)
  • Received:2005-04-13 Revised:2005-08-04 Published:2006-01-21
  • Contact: LI Yuan-Chao

A novel oxidant o-iodoxynaphthoic acid (INX) (1) was synthesized from 1-naphthonitrile in a four-step procedure with 38.5% overall yield. INX showed mild oxidative activity and selectivity in oxida-tion of a series of steroidal hydroxyl groups.

Key words: o-iodoxybenzoic acid (IBX), selective oxidation, steroidal hydroxyl group, o-iodoxynaphthoic acid (INX)