Synthesis and Biological Activity of 2-Indolyl Oxazoline and  Thiazoline Derivatives

Chin. J. Org. Chem. ›› 2008, Vol. 28 ›› Issue (10): 1841-1845. Previous Articles Next Articles

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2-吲哚基噁唑啉和噻唑啉衍生物的合成及生物活性研究

刘磊^a ; 郑中博^a; 覃兆海^a ; 傅滨^*,a ; 袁会珠^*,b

(a中国农业大学理学院北京100094)
(b中国农业科学院植保所北京100094)

收稿日期:2008-03-03 修回日期:2008-07-19 发布日期:2008-10-20
通讯作者: 傅滨; 袁会珠

Synthesis and Biological Activity of 2-Indolyl Oxazoline and Thiazoline Derivatives

LIU, Lei^a ; ZHENG, Zhong-Bo^a; QIN, Zhao-Hai ^a ; FU, Bin^*,a; YUAN, Hui-Zhu^*,b

(a College of Science, China Agricultural University, Beijing 100094)
(b Institute of Plant Protection, Chinese Academy of Agricultural Science, Beijing 100094)

Received:2008-03-03 Revised:2008-07-19 Published:2008-10-20
Contact: FU, Bin*;YUAN, Hui-Zhu*

Abstract

A series of novel 2-indolyl oxazoline and thiazoline derivatives were synthesized from 2-indolecarboxylic acid and enantiomerically amino alcohol, and characterized by IR, 1H NMR, mass spectra and elemental analysis. There bioassays were carried out. The preliminary results showed that all the title compounds had certain fungicidal activities against 10 kinds of bacterial. Thiazolines have much better fungicidal activities than oxazolines, especially, at the concentration of 50 mg/L the inhibition ratios of 2a and 2b were up to 100% against Phytophthora parasitica Dast, Sclerotinia sclerotiorum and Phomopsis asparagi (Sacc.) Bubak.

Key words: oxazoline, 2-indolyl, thiazoline, fungicide activity

Cite this article

LIU, Lei^a ; ZHENG, Zhong-Bo^a; QIN, Zhao-Hai ^a ; FU, Bin^*,a; YUAN, Hui-Zhu^*,b. Synthesis and Biological Activity of 2-Indolyl Oxazoline and Thiazoline Derivatives[J]. Chin. J. Org. Chem., 2008, 28(10): 1841-1845.

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2-吲哚基噁唑啉和噻唑啉衍生物的合成及生物活性研究

Synthesis and Biological Activity of 2-Indolyl Oxazoline and Thiazoline Derivatives

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