Synthesis and Biological Activities of 3-(1′-Alkyloxyimino)ethyl-4-hydroxy-pyrroline-2-one Derivatives

Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (11): 1784-1789. Previous Articles Next Articles

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3-(1′-烃氧亚氨基)乙基-4-羟基吡咯啉-2-酮类衍生物的合成与生物活性

朱宪杰^a 黄林^a 王先锋^a,b 朱兆勇^a 郑晓倩^a 强胜^c 杨春龙^*,a,b

(a南京农业大学理学院化学系南京 210095) (b南京农业大学农业部病虫监测与防控重点开放实验室南京 210095) (c南京农业大学生命科学学院南京 210095)

收稿日期:2009-01-13 修回日期:2009-04-24 发布日期:2009-06-16
通讯作者: 杨春龙 E-mail:chunlongyang@yahoo.com.cn
基金资助:
国家级.863计划

Synthesis and Biological Activities of 3-(1′-Alkyloxyimino)ethyl-4-hydroxy-pyrroline-2-one Derivatives

Zhu, Xianjie^a Huang, Lin^a Wang, Xianfeng ^a,b Zhu, Zhaoyong^a Zheng, Xiao-qian^a Qiang, Sheng^c Yang, Chunlong^*,a,b

(^a Department of Chemistry, College of Science, Nanjing Agricultural University, Nanjing 210095) (^b Key Laboratory of Monitoring and Management of Crop Diseases and Pest Insects, Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095) (c College of Life Science, Nanjing Agricultural University, Nanjing 210095)

Received:2009-01-13 Revised:2009-04-24 Published:2009-06-16

Abstract

3-Acetyl-4-hydroxypyrroline-2-one analogues (A) were synthesized using amino acid ethyl esters as starting material, which were reacted with alkyloxyamine hydrochlorides to give twenty oxime ether derivatives 3-(1'-alkyloxyiminoethyl)-4-hydroxypyrroline-2-ones (B). Structures of all the new compounds were confirmed by 1H NMR, MS, IR data and elemental analysis. The preliminary bioassay results indicated that this kind of compounds exhibited certain herbicidal and antifungal activities.

Key words: oxime ether, pyrroline-2-one, herbicidal activity, antifungal activity

Cite this article

SHU Xian-Jie, HUANG Lin, WANG Xian-Feng, SHU Zhao-Yong, ZHENG Xiao-Qian, JIANG Qing, YANG Chun-Long. Synthesis and Biological Activities of 3-(1′-Alkyloxyimino)ethyl-4-hydroxy-pyrroline-2-one Derivatives[J]. Chin. J. Org. Chem., 2009, 29(11): 1784-1789.

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3-(1′-烃氧亚氨基)乙基-4-羟基吡咯啉-2-酮类衍生物的合成与生物活性

Synthesis and Biological Activities of 3-(1′-Alkyloxyimino)ethyl-4-hydroxy-pyrroline-2-one Derivatives

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