Synthesis and Biological Activity of 6-(Substituted)-3-(3,4,5- trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (01): 137-141. Previous Articles Next Articles

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6-取代-3-（3，4，5-三甲氧基苯基）-1，2，4-三唑[3,4-b][1,3,4]噻二唑的合成与生物活性

杜海堂*，杜海军

(a天津大学理学院化学系天津 300072)
(b贵阳学院化学系贵阳 550003)
(c贵州民族学院化学与环境科学学院贵阳 550025)

收稿日期:2009-08-22 修回日期:2009-11-10 发布日期:2010-01-20
通讯作者: 杜海堂 E-mail:haitangdu@163.com

Synthesis and Biological Activity of 6-(Substituted)-3-(3,4,5- trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole

Du,Haitang*，Du,Haijun

(^aDepartment of Chemistry，College of Sciences，Tianjin Universty，Tianjin 300072)
(^b Department of Chemistry，Guiyang College，Guiyang 550003)
(^c School of Chemistry and Environment Science，Guizhou University for Nationalites，Guiyang 550025)

Received:2009-08-22 Revised:2009-11-10 Published:2010-01-20
Contact: DU Hai-Tang E-mail:haitangdu@163.com

Abstract

Eleven 6-(substituted)-3-(3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives 5a～5k were synthesized by cyclization of 4-amino-5-(3,4,5-trimethoxybenzyl)-3-mercapto-1,2,4- triazole (4) with various substituted aromatic acids through a single step reaction。IR，1H NMR，MS techniques and elemental analysis confirmed the structures of the newly synthesized compounds。Preliminary bioassays indicated that some compounds showed fungicidal activity.

Key words: 4-amino triazole, triazolo thiadiazole, fungicidal activity

Cite this article

DU Hai-Tang, DU Hai-Jun. Synthesis and Biological Activity of 6-(Substituted)-3-(3,4,5- trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole[J]. Chin. J. Org. Chem., 2010, 30(01): 137-141.

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6-取代-3-（3，4，5-三甲氧基苯基）-1，2，4-三唑[3,4-b][1,3,4]噻二唑的合成与生物活性

Synthesis and Biological Activity of 6-(Substituted)-3-(3,4,5- trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole

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