Efficient One-Pot Synthesis of β-Amino Ketone Derivatives Catalyzed by Aluminium p-Toluenesulfonate under Mild Conditions

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (02): 295-298. Previous Articles Next Articles

Notes

温和条件下对甲基苯磺酸铝高效催化一锅法合成β-氨基酮衍生物

王敏*^{,1，梁艳¹，宋志国²，姜恒³}

(¹渤海大学化学化工学院锦州 121000)
(²渤海大学科技实验中心锦州 121000)
(³辽宁石油化工大学石油化工学院抚顺 113001)

收稿日期:2009-05-05 修回日期:2009-07-09 发布日期:2010-02-20
通讯作者: 王敏 E-mail:minwangszg@yahoo.com.cn

Efficient One-Pot Synthesis of β-Amino Ketone Derivatives Catalyzed by Aluminium p-Toluenesulfonate under Mild Conditions

Wang Min*^{,1 Liang Yan¹ Song Zhiguo² Jiang Heng³}

(¹ College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121000)
(² Center for Science & Technology Experiment, Bohai University, Jinzhou 121000)
(³ College of Petrochemical Engineering, Liaoning Shihua University, Fushun 113001)

Received:2009-05-05 Revised:2009-07-09 Published:2010-02-20

Abstract

The three-component one-pot Mannich reaction of aromatic ketones, aromatic aldehydes and aromatic amines catalyzed by aluminium p-toluenesulfonate afforded the corresponding β-amino ketone derivatives efficiently at room temperature. The effects of different solvents and reaction conditions on the yields were investigated. After reaction, the catalyst could be easily recovered by phase separation and reused for many times without distinct decrease in its catalytic activity. The structures of products were characterized by IR, ¹H NMR spectra and elemental analysis.

Key words: aluminium p-toluenesulfonate, Mannich reaction, β-amino ketone derivative, one-pot synthe-sis, aromatic aldehyde

Cite this article

WANG Min, LIANG Yan, SONG Zhi-Guo, JIANG Heng. Efficient One-Pot Synthesis of β-Amino Ketone Derivatives Catalyzed by Aluminium p-Toluenesulfonate under Mild Conditions[J]. Chin. J. Org. Chem., 2010, 30(02): 295-298.

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温和条件下对甲基苯磺酸铝高效催化一锅法合成β-氨基酮衍生物

Efficient One-Pot Synthesis of β-Amino Ketone Derivatives Catalyzed by Aluminium p-Toluenesulfonate under Mild Conditions

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