Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (9): 2449-2453.DOI: 10.6023/cjoc201701046 Previous Articles     Next Articles



张文锋a, 许招会a, 涂缘鸿a, 廖传文bb   

  1. a 江西师范大学化学化工学院 南昌 330022;
    b 江西省人民医院普外科 南昌 330006
  • 收稿日期:2017-01-23 修回日期:2017-04-13 发布日期:2017-04-27
  • 通讯作者: 许招会
  • 基金资助:


Synthesis of 5,5-(Phenylmethylene)bis(2,2-butylidene-1,3-dioxane-4,6-dione) Derivatives without Catalyst in Water

Zhang Wenfenga, Xu Zhaohuia, Tu Yuanhonga, Liao Chuanwenb   

  1. a Department of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022;
    b Department of General Surgery, Jiangxi Province People's Hospital, Nanchang 330006
  • Received:2017-01-23 Revised:2017-04-13 Published:2017-04-27
  • Contact: 10.6023/cjoc201701046
  • Supported by:

    Project supported by the National Science and Technology Project (No. 2001BA323C) and the Graduate Innovation Foundation of Jiangxi Province (No. YC2015-B023).

A new simple and efficient synthesis of 5,5-(phenylmethylene)bis(2,2-butylidene-1,3-dioxane-4,6-dione) derivatives, based on aromatic aldehydes and 2,2-butylidene-1,3-dioxane-4,6-dione, via Tandem reaction of Knoevenagel condensation and Michael addition is described using water as solvent without catalyst. A variety of aromatic aldehydes were engaged in study and afforded respective products in high yields (63%~83%). The reaction has the advantages of mild conditions, simple operation and environmental friendliness.

Key words: aromatic aldehydes, tandem reaction, synthesis in water, catalyst-free