Synthesis and Characterization of Novel 3-(1,2,4-Triazol-1-yl)-1,5- benzo[b]thiazepine Derivatives

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (02): 244-249. Previous Articles Next Articles

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新型含1,2,4三唑基的1,5苯并硫氮杂的合成和表征

杨德保，刘方明*，沈松伟，陈盛钦

(杭州师范大学材料与化学化工学院杭州 310036)

收稿日期:2008-11-21 修回日期:2009-01-03 发布日期:2010-02-20

Synthesis and Characterization of Novel 3-(1,2,4-Triazol-1-yl)-1,5- benzo[b]thiazepine Derivatives

Yang Debao Liu Fangming* Shen Songwei Chen Shengqin

(College of Materials and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036)

Received:2008-11-21 Revised:2009-01-03 Published:2010-02-20

Abstract

The chalcones 2a～2l were synthesized by aldol condensation reaction of arylaldehydes with 1-aryl-2-(1H-1,2,4-triazol-1-yl)ethanones (1a～1c), which were prepared from 2-bromo-1-arylethanones. Then the intermediates 2a～2l were reacted with 2-aminobenzenethiol to give a series of 3-(1,2,4-triazol-1-yl)- benzo[b]thiazepine derivatives 3a～3l. Compounds 3a～3l were confirmed by means of elemental analysis, IR, ¹H NMR, MS techniques, and compounds 2a and 3a were analyzed by X-ray single-crystal diffraction.

Key words: chalcone, 1,2,4-triazole, 1,5-benzo[b]thiazepine, crystal structure

Cite this article

YANG De-Bao, LIU Fang-Meng, CHEN Song-Wei, CHEN Cheng-Qin. Synthesis and Characterization of Novel 3-(1,2,4-Triazol-1-yl)-1,5- benzo[b]thiazepine Derivatives[J]. Chin. J. Org. Chem., 2010, 30(02): 244-249.

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新型含1,2,4三唑基的1,5苯并硫氮杂的合成和表征

Synthesis and Characterization of Novel 3-(1,2,4-Triazol-1-yl)-1,5- benzo[b]thiazepine Derivatives

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