Three-Component One-Pot Synthesis of Quinazolin-4(3H)-one Derivatives Catalysed by Copper o-Toluenesulfonate under Mild Conditions

Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (05): 740-744. Previous Articles Next Articles

Notes

温和条件下邻甲基苯磺酸铜催化三组分“一锅法”合成喹唑啉-4(3H)-酮衍生物

王敏*^{,1，张婷婷¹，宋志国²}

(¹渤海大学化学化工学院锦州 121000)
(²渤海大学科技实验中心锦州 121000)

收稿日期:2009-09-08 修回日期:2009-11-25 发布日期:2009-12-17
通讯作者: 王敏 E-mail:minwangszg@yahoo.com.cn

Three-Component One-Pot Synthesis of Quinazolin-4(3H)-one Derivatives Catalysed by Copper o-Toluenesulfonate under Mild Conditions

Wang Min*^{,1 Zhang Tingting¹ Song Zhiguo²}

(¹ College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121000)
(² Center for Science & Technology Experiment, Bohai University, Jinzhou 121000)

Received:2009-09-08 Revised:2009-11-25 Published:2009-12-17

Abstract

Quinazolin-4(3H)-one derivatives were synthesized efficiently by a three components one-pot reaction of anthranilic acid, amines and ortho esters in the presence of copper o-toluenesulfonate at room temperature without solvent. The effects of molar ratio of raw materials and amount of catalysts on the yields were investigated. The result of catalyst circulation shows that there is no obvious change in its catalytic activity. The structures of products were characterized by melting points, IR, ¹H NMR and elemental analysis. In addition, the probable mechanism for the reaction was proposed.

Key words: copper o-toluenesulfonate, quinazolinone derivative, one-pot synthesis

Cite this article

WANG Min, ZHANG Ting-Ting, SONG Zhi-Guo. Three-Component One-Pot Synthesis of Quinazolin-4(3H)-one Derivatives Catalysed by Copper o-Toluenesulfonate under Mild Conditions[J]. Chin. J. Org. Chem., 2010, 30(05): 740-744.

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温和条件下邻甲基苯磺酸铜催化三组分“一锅法”合成喹唑啉-4(3H)-酮衍生物

Three-Component One-Pot Synthesis of Quinazolin-4(3H)-one Derivatives Catalysed by Copper o-Toluenesulfonate under Mild Conditions

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