One-Pot and Multicomponent Synthesis of N-Substituted-4-hydroxyl-2-pyridones

doi:10.6023/cjoc201801015

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (8): 2054-2059.DOI: 10.6023/cjoc201801015 Previous Articles Next Articles

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多组分一锅法合成N-取代-4-羟基-2-吡啶酮

白飞成, 胡德庆, 刘云云, 韦丽

江西师范大学化学化工学院南昌 330022

收稿日期:2018-01-08 修回日期:2018-03-21 发布日期:2018-04-27
通讯作者: 韦丽 E-mail:wl@jxnu.edu.cn
基金资助:
江西省教育厅基金（No.GJJ160328）和江西师范大学博士科研启动基金资助项目.

One-Pot and Multicomponent Synthesis of N-Substituted-4-hydroxyl-2-pyridones

Bai Feicheng, Hu Deqing, Liu Yunyun, Wei Li

College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022

Received:2018-01-08 Revised:2018-03-21 Published:2018-04-27
Contact: 10.6023/cjoc201801015 E-mail:wl@jxnu.edu.cn
Supported by:
Project supported by the Department of Education of Jiangxi Province (No. GJJ160328) and the Doctoral Start-up Fund of Jiangxi Normal University.

1. One-Pot and Multicomponent Synthesis of N-Substituted-4-hydroxyl-2-pyridones.PDF(1456KB)

Abstract

A series of 4-hydroxyl-2-pyridone derivatives were synthesized via a one-pot and multicomponent reaction of dimethyl 3-oxopentanedioate, N, N-dimethylformamide dimethyl acetal (DMF-DMA) and primary amine in aliphatic alcohol by using L-proline as catalyst. The structures of these compounds were confirmed by NMR and HRMS. This work provides a convenient method for construction of pyridones with the advantages of operation simplicity, free of isolating intermediates etc. Moreover, the participation of solvent in the reaction enriched the diversity of 5-substitution in the pyridone backbone.

Key words: 4-hydroxyl-2-pyridone, multicomponent reaction, dimethyl 3-oxopentanedioate, one-pot synthesis

Cite this article

Bai Feicheng, Hu Deqing, Liu Yunyun, Wei Li. One-Pot and Multicomponent Synthesis of N-Substituted-4-hydroxyl-2-pyridones[J]. Chin. J. Org. Chem., 2018, 38(8): 2054-2059.

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多组分一锅法合成N-取代-4-羟基-2-吡啶酮

One-Pot and Multicomponent Synthesis of N-Substituted-4-hydroxyl-2-pyridones

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