Synthesis and Biological Activity of α-Aminophosphonate Derivatives Containing Novel Substituted Pyrazole

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (01): 63-67. Previous Articles Next Articles

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新型含吡唑基的α-氨基膦酸酯类衍生物的合成及生物活性

仇记宽¹，刘国生²，李建平*^{,1，赵玉灵¹，李会娟¹，张贵生¹}

(¹河南师范大学化学与环境科学学院黄淮水环境与污染防治省部共建教育部重点实验室新乡 453007)
(²河南师范大学生命科学学院新乡 453007)

收稿日期:2010-03-30 修回日期:2010-06-23 发布日期:2010-08-09
通讯作者: 李建平 E-mail:jplig@163.com
基金资助:
国家自然科学基金;河南省高校科技创新团队支持计划

Synthesis and Biological Activity of α-Aminophosphonate Derivatives Containing Novel Substituted Pyrazole

Qiu Jikuan¹ Liu Guosheng² Li Jian-ping*^{,1 Zhao Yuling¹ Li Huijuan¹ Zhang Guisheng¹}

(¹Key Labaratory for Yellow River and Huaihe River Water Environment and Pollution Control, Ministry of Education, College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007)
(²College of Life Science, Henan Normal University, Xinxiang 453007)

Received:2010-03-30 Revised:2010-06-23 Published:2010-08-09

Abstract

A series of novel α-aminophosphonate derivatives containing substituted pyrazole were synthesized with substituted pyrazolyl aldehyde, arylamine and diethylphosphone under microwave-assisted without using any catalysts and solvent. And the structures of the compounds were confirmed by ¹H NMR,¹³C NMR, ³¹P NMR and MS techniques. Preliminary bioassay indicated that some of them showed good fungicidal activities.

Key words: pyrazole, aminophosphonate, microwave-assisted solvent-free synthesis, biological activity

Cite this article

CHOU Ji-Kuan, LIU Guo-Sheng, LI Jian-Ping, ZHAO Yu-Ling, LI Hui-Juan, ZHANG Gui-Sheng. Synthesis and Biological Activity of α-Aminophosphonate Derivatives Containing Novel Substituted Pyrazole[J]. Chin. J. Org. Chem., 2011, 31(01): 63-67.

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新型含吡唑基的α-氨基膦酸酯类衍生物的合成及生物活性

Synthesis and Biological Activity of α-Aminophosphonate Derivatives Containing Novel Substituted Pyrazole

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