Synthesis and Antifungal Activity of 2-Carboxamide-4-aryl- 1,5-benzothiazepines

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (08): 1252-1257. Previous Articles Next Articles

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C(2)-酰胺基取代的1,5-苯并硫氮杂卓的合成及抑菌活性的研究

李文红³，张玲芬¹，刘薇²，杜星琼²，李媛*^,1

(¹河北师范大学化学与材料科学学院石家庄 050016)
(²河北师范大学生命科学学院石家庄 050016)
(³河北工业职业技术学院环境与化学工程系石家庄 050091)

收稿日期:2010-12-30 修回日期:2011-04-22 发布日期:2011-05-03
通讯作者: 李媛 E-mail:yuanli@mail.hebtu.edu.cn
基金资助:
国家自然科学基金;河北省自然科学基金

Synthesis and Antifungal Activity of 2-Carboxamide-4-aryl- 1,5-benzothiazepines

Li Wenhong³ Zhang Lingfen¹ Liu Wei² Du Xingqiong² Li Yuan*^,1

(¹College of Chemistry & Material Science, Hebei Normal University, Shijiazhuang 050016)
(²College of Life Sciences, Hebei Normal University, Shijiazhuang 050016)
(³Environment and Chemical Engineering, Hebei College of Industry and Technol-ogy, Shijiazhuang 050091)

Received:2010-12-30 Revised:2011-04-22 Published:2011-05-03

Three kinds of 2-carboxamide-1,5-benzothiazepines including 2-carboxamide(N-aryl)-4-aryl, 2-carboxamide-(N-alkyl)-4-aryl and 2-carboxamide-(N,N-alkyl)-4-aryl-1,5-benzothiazepines were designed and synthesized, and their structures were characterized by elemental analysis, IR, ¹H NMR, and MS techniques. Their antifungal activities against some fungi were evaluated, and the results indicated that some of them showed moderate fungicidal activities in vitro against C. neoformans. The synthesis condi-tions of the title compounds were also investigated.

Key words: 1,5-benzothiazepine, carboxamide, antifungal activity

Cite this article

LI Wen-Hong, ZHANG Ling-Fen, LIU Wei, DU Xing-Qiong, LI Yuan. Synthesis and Antifungal Activity of 2-Carboxamide-4-aryl- 1,5-benzothiazepines[J]. Chin. J. Org. Chem., 2011, 31(08): 1252-1257.

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C(2)-酰胺基取代的1,5-苯并硫氮杂卓的合成及抑菌活性的研究

Synthesis and Antifungal Activity of 2-Carboxamide-4-aryl- 1,5-benzothiazepines

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