Synthesis of 2-Diethyl Phosphate Heterocyclic Ketene Aminals

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (9): 1504-1509. Previous Articles Next Articles

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2-亚磷酸二乙酯基杂环烯酮缩胺类化合物的合成

余富朝，严胜骄，贺能琴，林军*

(云南大学化学科学与工程学院教育部自然资源药物化学重点实验室昆明 650091)

收稿日期:2010-10-27 修回日期:2011-02-16 发布日期:2011-04-27
通讯作者: 林军 E-mail:linjun@ynu.edu.cn;linjunyn@yahoo.com.cn

Synthesis of 2-Diethyl Phosphate Heterocyclic Ketene Aminals

YU Fu-Chao, YAN Sheng-Jiao, HE Neng-Qin, LIN Jun

(Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091)

Received:2010-10-27 Revised:2011-02-16 Published:2011-04-27

Mercaptals (1), with low-cost and readily available Mn(OAc)₂-KMnO₄ system instead of the expensive Mn(OAc)₃ as catalyst, reacted with diethyl phosphite to give novel 2-diethyl phosphate mercaptals (2a～2d). Sequentially, compounds 2a～2d reacted with diamines (3) to afford a series of 2-diethyl phosphate heterocyclic ketene amines (4) with good yields.

Key words: diethyl phosphite, manganese(II) acetate, free radical reaction, heterocyclic ketene aminal

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YU Fu-Chao, YAN Sheng-Jiao, HE Neng-Qin, LIN Jun. Synthesis of 2-Diethyl Phosphate Heterocyclic Ketene Aminals[J]. Chin. J. Org. Chem., 2011, 31(9): 1504-1509.

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2-亚磷酸二乙酯基杂环烯酮缩胺类化合物的合成

Synthesis of 2-Diethyl Phosphate Heterocyclic Ketene Aminals

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