Synthesis and Anti-bacterial Activity of Novel Chalcone Derivatives Containing 2,4-Thiazolidinedione-3-acetic Acid Moiety

doi:10.6023/cjoc1107182

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (01): 183-188.DOI: 10.6023/cjoc1107182 Previous Articles Next Articles

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含噻唑烷二酮-3-乙酸结构查尔酮衍生物的合成及抗菌活性的研究

孟凡领, 郑昌吉, 李因晶, 孙良鹏, 刘学坤, 张天一, 朴虎日

延边大学药学院长白山生物资源与功能分子教育部重点实验室延吉 133002

收稿日期:2011-07-18 修回日期:2011-09-14 发布日期:2011-09-14
通讯作者: 朴虎日 E-mail:piaohr@ybu.edu.cn
基金资助:
国家自然科学基金(No. 20962021)资助项目.

Synthesis and Anti-bacterial Activity of Novel Chalcone Derivatives Containing 2,4-Thiazolidinedione-3-acetic Acid Moiety

Meng Fanling, Zheng Changji, Li Yinjing, Sun Liangpeng, Liu Xuekun, Zhang Tianyi, Piao Huri

Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002

Received:2011-07-18 Revised:2011-09-14 Published:2011-09-14
Contact: Hu-Ri Piao E-mail:piaohr@ybu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (No. 20962021).

A series of novel chalcone derivatives bearing the 2,4-thiazolidinedione-3-acetic acid moieties (8a～8p) were synthesized, and evaluated for their anti-bacterial activity. The results demonstrated that some compounds presented good antimicrobial activities against four multidrug-resistant clinical isolates, among which compounds 8g, 8i, 8l and 8m with minimum inhibitory concentration (MIC) value of 4 μg/mL showed as active as the standard drug, norfloxacin, against methicillin- resistant S. aureus. None of the compounds exhibited obvious activity against the Gram-negative bacteria E. coli 1356 at 64 μg/mL.

Key words: chalcone, 2,4-thiazolidinedione-3-acetic acid, anti-bacterial activity

Cite this article

Meng Fanling, Zheng Changji, Li Yinjing, Sun Liangpeng, Liu Xuekun, Zhang Tianyi, Piao Huri . Synthesis and Anti-bacterial Activity of Novel Chalcone Derivatives Containing 2,4-Thiazolidinedione-3-acetic Acid Moiety[J]. Chin. J. Org. Chem., 2012, 32(01): 183-188.

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含噻唑烷二酮-3-乙酸结构查尔酮衍生物的合成及抗菌活性的研究

Synthesis and Anti-bacterial Activity of Novel Chalcone Derivatives Containing 2,4-Thiazolidinedione-3-acetic Acid Moiety

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