Synthesis and Biological Activity of New 5-Heteroaryl-2-pyridone Derivatives

doi:10.6023/cjoc1107161

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (01): 88-94.DOI: 10.6023/cjoc1107161 Previous Articles Next Articles

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新型吡啶-2-酮类衍生物的合成及生物活性

曾永明^a, 沈松伟^b, 刘方明^a,b

a 新疆大学化学化工学院乌鲁木齐 830046;
b 杭州师范大学材料与化学化工学院杭州 310036

收稿日期:2011-07-16 修回日期:2011-07-30 发布日期:2011-09-27
通讯作者: 曾永明 E-mail:zym903@126.com
基金资助:
国家自然科学基金(Nos. 29702007, 20162004)资助项目.

Synthesis and Biological Activity of New 5-Heteroaryl-2-pyridone Derivatives

Zeng Yongming^a, Shen Songwei^b, Liu Fangming^a,b

a College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046;
b College of Materials and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036

Received:2011-07-16 Revised:2011-07-30 Published:2011-09-27
Contact: Yong-Ming Zeng E-mail:zym903@126.com
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 29702007, 20162004).

Eighteen title pyridone compounds containing the 1,3,4-oxadiazoline or 1,3,4-thiadiazine group were synthesized by the multi-step reaction using 5-acetyl-3-cyano-2-methyl-2-pyridone as stating materials. Structures of new compounds were characterized by ¹H NMR, IR, MS techniques and elemental analysis. Compound 4a was further studied by single crystal X-ray diffraction analysis. The results of antibacterial activity experiment indicated that all compounds were all resistant to three different bacterias with various degrees.

Key words: 1,3,4-oxadiazoline, s-triazolo[3,4-b][1,3,4]thiadiazine, crystal structure, biological activity

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Zeng Yongming, Shen Songwei, Liu Fangming . Synthesis and Biological Activity of New 5-Heteroaryl-2-pyridone Derivatives[J]. Chin. J. Org. Chem., 2012, 32(01): 88-94.

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新型吡啶-2-酮类衍生物的合成及生物活性

Synthesis and Biological Activity of New 5-Heteroaryl-2-pyridone Derivatives

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