Synthesis of Multisubstituted Indenes by Fe(III)-Catalyzed Friedel-Crafts Cyclization of Allylic Alcohols

doi:10.6023/cjoc1202271

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (08): 1533-1538.DOI: 10.6023/cjoc1202271 Previous Articles Next Articles

Notes

Fe(III)催化的烯丙醇的Friedel-Crafts环化反应合成多取代茚

张继坦, 张金花, 方旷, 束官莹, 谢美华

安徽师范大学化学与材料科学学院芜湖 241000

收稿日期:2012-02-27 修回日期:2012-04-11 发布日期:2012-04-24
通讯作者: 谢美华 E-mail:xiemh@mail.ahnu.edu.cn
基金资助:
国家自然科学基金(No. 20772001)资助项目.

Synthesis of Multisubstituted Indenes by Fe(III)-Catalyzed Friedel-Crafts Cyclization of Allylic Alcohols

Zhang Jitan, Zhang Jinhua, Fang Kuang, Shu Guanying, Xie Meihua

College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000

Received:2012-02-27 Revised:2012-04-11 Published:2012-04-24
Supported by:
Project supported by the National Natural Science Foundation of China (No. 20772001).

FeCl₃?6H₂O-catalyzed intramolecular Friedel-Crafts cyclization of multisubstituted allylic alcohols proceeded smoothly and a series of multisubstituted indenes were synthesized in moderate to high yields. The reaction has the advantages of simple manipulation and mild reaction conditions. The products were characterized by IR, ¹H NMR, ¹³C NMR, HR MS and X-ray diffraction analysis.

Key words: allylic alcohol, FeCl₃?6H₂O, Friedel-Crafts cyclization, indene

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Zhang Jitan, Zhang Jinhua, Fang Kuang, Shu Guanying, Xie Meihua. Synthesis of Multisubstituted Indenes by Fe(III)-Catalyzed Friedel-Crafts Cyclization of Allylic Alcohols[J]. Chin. J. Org. Chem., 2012, 32(08): 1533-1538.

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Fe(III)催化的烯丙醇的Friedel-Crafts环化反应合成多取代茚

Synthesis of Multisubstituted Indenes by Fe(III)-Catalyzed Friedel-Crafts Cyclization of Allylic Alcohols

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