Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (10): 1999-2002.DOI: 10.6023/cjoc201204004 Previous Articles     Next Articles

Notes

无溶剂条件下简单、有效的合成多取代环己醇

荣良策a,b, 魏贤勇a, 路瑶a, 宗志敏 a   

  1. a 中国矿业大学化工学院 徐州 221008;
    b 江苏师范大学化学化工学院 徐州 221116
  • 收稿日期:2012-04-05 修回日期:2012-05-15 发布日期:2012-06-04
  • 通讯作者: 荣良策, 魏贤勇 E-mail:lcrong@jsnu.edu.cn or lcrong2005@yahoo.com
  • 基金资助:

    江苏省高校自然科学基础研究基金(No. 08KJB150017)和江苏师范大学科研平台(No. 10XLS02)资助项目.

A Facile and Efficient Synthesis of Polysubstituted Cyclohexanol Derivatives under Solvent-Free Conditions

Rong Liangcea,b, Wei Xianyonga, Lu Yaoa, Zong Zhimina   

  1. a School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221008;
    b College of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116
  • Received:2012-04-05 Revised:2012-05-15 Published:2012-06-04
  • Supported by:

    Project supported by the Natural Science Foundation of Jiangsu Education Department (No. 08KJB150017) and the Foundation of Xuzhou Normal University (No. 10XLS02).

A facile and efficient synthesis of polysubstituted cyclohexanol derivatives by the addition and cyclization reaction of substituted acetophenone and chalcone in the presence of NaOH under solvent-free conditions is reported. This protocol has the advantages of shorter reaction time, mild conditions, easy work-up, and environmental friendliness. The products were identified by IR, 1H NMR and elemental analysis. The solvent-free method is the efficient approach for the synthesis of these compounds.

Key words: chalcone, cyclohexanol, solvent-free reaction, Michael addition, aldol condensations