Design, Synthesis, and Biological Evaluation of N-Aryl-salicylamide Derivatives as Potential Antitumor Agents

doi:10.6023/cjoc201211052

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (05): 1026-1034.DOI: 10.6023/cjoc201211052 Previous Articles Next Articles

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水杨酰芳胺类化合物的设计、合成及体外抗肿瘤活性研究

王杰^a, 邬皓^a, 李家明^a, 许勤龙^a, 何广卫^b, 钟国琛^a, 张艳春^a

a 安徽中医学院药学院安徽省现代中药重点实验室合肥 230031;
b 合肥医工医药有限公司合肥 230059

收稿日期:2012-12-03 修回日期:2013-01-15 发布日期:2013-01-21
通讯作者: 李家明,lijiaming2004@sina.com E-mail:lijiaming2004@sina.com
基金资助:
安徽省自然科学基金(No. 1208085MH128)、国家创新药物孵化基地(No. 2012ZX09401066)资助项目

Design, Synthesis, and Biological Evaluation of N-Aryl-salicylamide Derivatives as Potential Antitumor Agents

Wang Jie^a, Wu Hao^a, Li Jiaming^a, Xu Qinlong^a, He Guangwei^b, Zhong Guochen^a, Zhang Yanchun^a

a Anhui Key Laboratory of Traditional Chinese Medicine, Department of Pharmacy, Anhui College of Traditional Chinese Medicine, Hefei 230031;
b Hefei Medical Engineering Pharmaceutical Co, Ltd., Hefei 230059

Received:2012-12-03 Revised:2013-01-15 Published:2013-01-21

According to the scaffold hopping, a series of N-aryl-salicylamide derivatives, which have fragments of tyrosine kinase inhibitors lapatinib and neratinib were designed and synthesized. Their structures were identified by IR, ¹H NMR, ¹³C NMR and MS techniques. The target compounds were tested for cytotoxic activity against four cancer cell lines, including A549, MCF-7, SGC-7901, Bel-7402, by methyl thiazolyl tetrazolium (MTT) in vitro. All the compounds demonstrated certain antitumor abilities, and some of them were better than gefitinib.

Key words: N-aryl-salicylamide, tyrosine kinase inhibitors, antitumor

Cite this article

Wang Jie, Wu Hao, Li Jiaming, Xu Qinlong, He Guangwei, Zhong Guochen, Zhang Yanchun. Design, Synthesis, and Biological Evaluation of N-Aryl-salicylamide Derivatives as Potential Antitumor Agents[J]. Chin. J. Org. Chem., 2013, 33(05): 1026-1034.

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水杨酰芳胺类化合物的设计、合成及体外抗肿瘤活性研究

Design, Synthesis, and Biological Evaluation of N-Aryl-salicylamide Derivatives as Potential Antitumor Agents

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