Synthesis and Anticancer Activities of C-13 Etheral Gibberellin Derivatives

doi:10.6023/cjoc201309031

Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (4): 788-796.DOI: 10.6023/cjoc201309031 Previous Articles Next Articles

Articles

C-13位烷氧基赤霉素衍生物的合成与抗肿瘤活性研究

陈静波^a, 孙竹仙^a, 张雁丽^b, 陈景超^a, 李鹏辉^a, 曾祥慧^a, 尹本林^a, 谢彦^a, 卿晨^b, 张洪彬^a

a 云南大学化学科学与工程学院自然资源药物化学教育部重点实验室昆明 650091;
b 昆明医科大学云南省自然资源药理重点实验室昆明 650031

收稿日期:2013-09-23 修回日期:2013-12-05 发布日期:2013-12-13
通讯作者: 陈静波，卿晨，张洪彬 E-mail:zhanghb@ynu.edu.cn
基金资助:
国家自然科学基金（Nos. 21062029，20925205）、云南省自然科学基金（Nos. 2009CD007，2010GA014）及国家基础研究（973项目，No. 2009CB522300）资助项目.

Synthesis and Anticancer Activities of C-13 Etheral Gibberellin Derivatives

Chen Jingbo^a, Sun Zhuxian^a, Zhang Yanli^b, Chen Jingchao^a, Li Penghui^a, Zeng Xianghui^a, Yin Benlin^a, Xie Yan^a, Qing Chen^b, Zhang Hongbin ^a

a Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091;
b Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650031

Received:2013-09-23 Revised:2013-12-05 Published:2013-12-13
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21062029, 20925205), the Natural Science Foundation of Yunan Province (Nos. 2009CD007, 2010GA014) and the National Basic Research Program of China (973 Program, No. 2009CB522300).

Abstract

C-13 ethereal gibberellin derivatives bearing two α,β-unsaturated ketones in A and D rings have been designed and synthesized. In vitro studies demonstrated that a number of the C-13 ethereal gibberellin derivatives showed strong anticancer activities in thiazolylblue (MTT) assay towards four human cancer cell lines including HT29, A-549, HepG2 and MKN28. Compound 27 was found to be the most potent compound (IC₅₀=0.21 μmol·L^-1 against MKN28) and more active than the positive control (DDP).

Key words: gibberellin, ether, α,β-unsaturated ketone, anticancer

Cite this article

Chen Jingbo, Sun Zhuxian, Zhang Yanli, Chen Jingchao, Li Penghui, Zeng Xianghui, Yin Benlin, Xie Yan, Qing Chen, Zhang Hongbin . Synthesis and Anticancer Activities of C-13 Etheral Gibberellin Derivatives[J]. Chin. J. Org. Chem., 2014, 34(4): 788-796.

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C-13位烷氧基赤霉素衍生物的合成与抗肿瘤活性研究

Synthesis and Anticancer Activities of C-13 Etheral Gibberellin Derivatives

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