Catalytic Asymmetric Synthesis of Chiral Acetals

doi:10.6023/cjoc201503010

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (8): 1641-1649.DOI: 10.6023/cjoc201503010 Previous Articles Next Articles

REVIEW

手性缩醛的催化不对称合成研究进展

杜鹏, 周海峰, 沈冠硕, 邹坤

三峡大学生物与制药学院天然产物研究与利用湖北省重点实验室宜昌 443002

收稿日期:2015-03-09 修回日期:2015-03-30 发布日期:2015-04-10
通讯作者: 周海峰 E-mail:haifeng-zhou@hotmail.com
基金资助:
国家自然科学青年基金(No. 21202092)和三峡大学人才科研启动基金(No. KJ2012B080)资助项目.

Catalytic Asymmetric Synthesis of Chiral Acetals

Du Peng, Zhou Haifeng, Shen Guanshuo, Zou Kun

Hubei Key Laboratory of Natural Products Research & Development, College of Biological & Pharmaceutical Sciences, China Three Gorges University, Yichang 443002

Received:2015-03-09 Revised:2015-03-30 Published:2015-04-10
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21202092) and the Startup Foundation from China Three Gorges University (No. KJ2012B080).

Acetals are common building blocks of many drugs and natural product molecules. It was found that the biological activity of chiral acetals is usually superior to their racemates. The catalytic asymmetric synthesis of chiral acetals is challenge for its racemization and attracts attention until recent years. In this review, the recent studies on catalytic asymmetric synthesis of chiral aminals, N,O-acetals, N,S-acetals, O,O-acetals, as well as its application in synthesis of chiral drugs containing acetal moieties are reviewed.

Key words: chiral acetals, catalytic asymmetric synthesis, chiral phosphoric acid

Cite this article

Du Peng, Zhou Haifeng, Shen Guanshuo, Zou Kun. Catalytic Asymmetric Synthesis of Chiral Acetals[J]. Chin. J. Org. Chem., 2015, 35(8): 1641-1649.

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手性缩醛的催化不对称合成研究进展

Catalytic Asymmetric Synthesis of Chiral Acetals

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