Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (3): 791-808.DOI: 10.6023/cjoc202211043 Previous Articles     Next Articles

Special Issue: 中国女科学家专辑



向勋a,b, 何照林a,*(), 董秀琴b,*()   

  1. a 武汉工程大学化学与环境工程学院 武汉 430205
    b 武汉大学化学与分子科学学院 有机硅化合物及材料教育部工程中心 武汉 430072
  • 收稿日期:2022-11-30 修回日期:2023-02-16 发布日期:2023-02-27
  • 通讯作者: 何照林, 董秀琴
  • 基金资助:
    国家自然科学基金(22071187); 国家自然科学基金(22271226); 湖北省自然科学基金(2020CFA036); 湖北省自然科学基金(2021CFA069); 国家青年拔尖人才资助项目

Recent Advances of Efficient Synthesis of Chiral Molecules Promoted by Pd/Chiral Phosphoric Acid Synergistic Catalysis

Xun Xianga,b, Zhaolin Hea(), Xiuqin Dongb()   

  1. a School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205
    b Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072
  • Received:2022-11-30 Revised:2023-02-16 Published:2023-02-27
  • Contact: Zhaolin He, Xiuqin Dong
  • Supported by:
    National Natural Science Foundation of China(22071187); National Natural Science Foundation of China(22271226); Natural Science Foundation of Hubei Province(2020CFA036); Natural Science Foundation of Hubei Province(2021CFA069); National Youth Talent Support Program

Transition metal palladium-catalyzed asymmetric reaction is an important and efficient method to synthesize chiral compounds. It has made considerable progress and achieved great success in the past decades. However, some reactions could not achieve high reactivity and excellent stereoselectivity just promoted by transition metal palladium catalysis. Therefore, it is of great significance to combine transition metal palladium catalysis and organocatalysis, which could be conducive to dissolve these challenging problems and received great attention. In recent years, a variety of asymmetric catalytic reactions have been efficiently realized by the synergistic catalysis system of transition metal palladium catalysis and chiral phosphoric acids with high chemo-, regio-, and stereoselectivity, and considerable research results and some important breakthroughs have been achieved. The recent progress of asymmetric allylation reaction, C(sp3)—H, C(sp2)—H functionalization and other reactions promoted by this synergistic catalysis system is summarized, the interaction between catalysts and substrates is systematically analyzed, and the influence factors of reactivity and selectivity are deeply discussed.

Key words: synergistic catalysis, Pd catalysis, chiral phosphoric acid, chiral compound, stereoselectivity