Synthesis and Biological Activity of 2-Methyl-6-chlorobenzene-sulfonylurea Derivatives

doi:10.6023/cjoc201501032

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (7): 1576-1581.DOI: 10.6023/cjoc201501032 Previous Articles Next Articles

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2-甲基-6-氯苯基磺酰脲衍生物的合成及生物活性

陈伟, 魏巍, 吴长春, 李玉新, 李永红, 于淑晶, 李正名

南开大学元素有机化学国家重点实验室化学化工协同创新中心天津天津 300071

收稿日期:2015-01-22 修回日期:2015-02-25 发布日期:2015-07-24
通讯作者: 李正名 E-mail:nkzml@vip.163.com
基金资助:
国家自然科学基金(No. 21272129)和国家科技部科技支撑计划(No. 2011BAE06B05)资助项目.

Synthesis and Biological Activity of 2-Methyl-6-chlorobenzene-sulfonylurea Derivatives

Chen Wei, Wei Wei, Wu Changchun, Li Yuxin, Li Yonghong, Yu Shujing, Li Zhengming

State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering Tianjin, Nankai University, Tianjin 30007

Received:2015-01-22 Revised:2015-02-25 Published:2015-07-24
Supported by:
Project supported by the National Natural Scinece Foundation of China (No. 21272129) and the National Key Technologies R&D Program (No. 2011BAE06B05).

1. Synthesis and Biological Activity of 2-Methyl-6-chlorobenzene-sulfonylurea Derivatives.PDF(4742KB)

Abstract

In order to study the multi-bioactivity of sulfonylurea (SU) derivatives, twelve novel 2-methyl-6-chlorobenzenesul-fonylureas were designed and synthesized according to the commercialized SUs skeletons. Their structures were confirmed by ¹H NMR, ¹³C NMR and HRMS. The title compounds showed good herbicidal activity against dicotyledonous weeds by pot-culture method. For example, the herbicidal activity of 5b, 5i and 5j against Brassica napus, Amaranthus retroflexus was as effective as chlorsulfuron and monosulfuron. The in vitro antifungal test indicated that some of the target compounds exhibited good antifungal activity at the dosage of 50 mg·L^-1.

Key words: sulfonylurea, chlorsulfuron, herbicidal activity, antifungal activity

Cite this article

Chen Wei, Wei Wei, Wu Changchun, Li Yuxin, Li Yonghong, Yu Shujing, Li Zhengming. Synthesis and Biological Activity of 2-Methyl-6-chlorobenzene-sulfonylurea Derivatives[J]. Chin. J. Org. Chem., 2015, 35(7): 1576-1581.

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2-甲基-6-氯苯基磺酰脲衍生物的合成及生物活性

Synthesis and Biological Activity of 2-Methyl-6-chlorobenzene-sulfonylurea Derivatives

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