Synthesis of Arylnaphthalene Lignan Lactones

doi:10.6023/cjoc201603007

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (11): 2723-2728.DOI: 10.6023/cjoc201603007 Previous Articles Next Articles

Notes

苯基萘类木脂素内酯的化学合成

孟瑾, 杜利月, 郭留城

漯河医学高等专科学校药学系河南漯河 462002

收稿日期:2016-03-06 修回日期:2016-07-21 发布日期:2016-08-10
通讯作者: 孟瑾 E-mail:mz_511310@163.com

Synthesis of Arylnaphthalene Lignan Lactones

Meng Jin, Du Liyue, Guo Liucheng

Department of Pharmacy, Luohe Medical College, Luohe, Henan 462002

Received:2016-03-06 Revised:2016-07-21 Published:2016-08-10

1. Synthesis of Arylnaphthalene Lignan Lactones.PDF(1120KB)

Abstract

Arylnaphthalene lignan lactones, widely distributed in plants, are a class of natural products containing the phenyl-naphthyl skeleton. These compounds have attracted considerable attention of many scientists for decades because of their wide biological activities. In this study, a convenient method is presented for the multiple parallel synthesis of arylnaphthalene lignans. With vanillic acid as starting material, six arylnaphthalene nature products were prepared in the process with 8 steps, via Diels-Alder reaction, Suzuki reaction and Fetizon oxidation as the key reactions.

Key words: Arylnaphthalene lignan lactones, Diels-Alder reaction, Suzuki-Miyaura coupling, Fetizon oxidation

Cite this article

Meng Jin, Du Liyue, Guo Liucheng. Synthesis of Arylnaphthalene Lignan Lactones[J]. Chin. J. Org. Chem., 2016, 36(11): 2723-2728.

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苯基萘类木脂素内酯的化学合成

Synthesis of Arylnaphthalene Lignan Lactones

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