Progress in Separation-Friendly Mitsunobu Reactions

doi:10.6023/cjoc201606029

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (12): 2880-2887.DOI: 10.6023/cjoc201606029 Previous Articles Next Articles

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分离友好的Mitsunobu反应研究进展

戚娜, 郭键, 贺耘

重庆大学药学院创新药物研究中心重庆 401331

收稿日期:2016-06-20 修回日期:2016-07-26 发布日期:2016-08-12
通讯作者: 郭键, 贺耘 E-mail:guojian5218@163.com;yun.he@cqu.edu.cn

Progress in Separation-Friendly Mitsunobu Reactions

Qi Na, Guo Jian, He Yun

School of Pharmaceutical Sciences and Innovative Drug Research Centre, Chonqing University, Chongqing 401331

Received:2016-06-20 Revised:2016-07-26 Published:2016-08-12

The Mitsunobu reaction is famous for its mild conditions, good stereoselectivities and extensive applications. But it is also infamous for difficult purification in organic synthetic chemistry, because of the formation of by-products such as phosphine oxide and hydrazine derivatives. To simplify the separation and improve the efficiency of purification is a hot topic in the research of Mitsunobu reaction. Various emerging strategies for product isolation in Mitsunobu reactions are reviewed. Special stress is laid on the principle, advantages and disadvantages of these strategies.

Key words: Mitsunobu reaction, separation strategy, simplified separation

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Qi Na, Guo Jian, He Yun. Progress in Separation-Friendly Mitsunobu Reactions[J]. Chin. J. Org. Chem., 2016, 36(12): 2880-2887.

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分离友好的Mitsunobu反应研究进展

Progress in Separation-Friendly Mitsunobu Reactions

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