Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (1): 29-38.DOI: 10.6023/cjoc201406003 Previous Articles     Next Articles



王小龙, 杨芳, 薛自燕, 王晓强   

  1. 兰州交通大学化学与生物工程学院 兰州 730070
  • 收稿日期:2014-06-04 修回日期:2014-08-29 发布日期:2014-09-18
  • 通讯作者: 王小龙
  • 基金资助:

    兰州交通大学青蓝人才工程基金(No. QL-06-01A)资助项目.

Progress of Mitsunobu Reaction in Construction of Chemical Bonds

Wang Xiaolong, Yang Fang, Xue Ziyan, Wang Xiaoqiang   

  1. School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070
  • Received:2014-06-04 Revised:2014-08-29 Published:2014-09-18
  • Supported by:

    Project supported by the Qing Lan Talent Engineering Funds of Lanzhou Jiaotong University (No. QL-06-01A).

The Mitsunobu reaction is an effective method for making a new chemical bond by condensation of an alcohol with an acidic compound. It can be applied for the construction of C—O, C—N, C—S and C—C bonds, and has been widely used in the synthesis of natural products and functional organic molecules. In this review, the mechanism of the Mitsunobu reaction and its application in the construction of chemical bonds are introduced. Moreover, the regioselectivity of this reaction is systematically summarized.

Key words: Mitsunobu reaction, chemical bond, reaction mechanism, stereoselectivity, regioselectivity