N-Iodosuccinimide-Promoted Regioselective Arylsulfenylation of Imidazo[1,2-a]pyridines with Disulfides

doi:10.6023/cjoc201609033

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (3): 720-725.DOI: 10.6023/cjoc201609033 Previous Articles Next Articles

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N-碘代丁二酰亚胺促进的咪唑并[1,2-a]吡啶衍生物的芳烃硫基化反应

安艳妮, 李建晓, 李蒙, 李春生, 杨少容

华南理工大学化学与化工学院广州 510640

收稿日期:2016-09-29 修回日期:2016-11-07 发布日期:2016-11-17
通讯作者: 杨少容,E-mail:lisryang@scut.edu.cn E-mail:lisryang@scut.edu.cn
基金资助:
国家自然科学基金（No.21502055）、中央高校基本科研业务费（No.2015ZM150）和中国博士后科学基金（Nos.2015M572303，2016T90779）资助项目.

N-Iodosuccinimide-Promoted Regioselective Arylsulfenylation of Imidazo[1,2-a]pyridines with Disulfides

An Yanni, Li Jianxiao, Li Meng, Li Chunsheng, Yang Shaorong

School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640

Received:2016-09-29 Revised:2016-11-07 Published:2016-11-17
Contact: 10.6023/cjoc201609033 E-mail:lisryang@scut.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21502055), the Fundamental Research Funds for the Central Universities (No. 2015ZM150) and the China Postdoctoral Science Foundation (Nos. 2015M572303, 2016T90779).

1. N-Iodosuccinimide-Promoted Regioselective Arylsulfenylation of Imidazo[1,2-a]pyridines with Disulfides.PDF(718KB)

Abstract

An efficient and practical N-iodosuccinimide-promoted regioselective arylsulfenylation of imidazo[1,2-a]pyridines with disulfides has been developed to afford functionalized 3-sulfenylimidazo[1,2-a]pyridines heterocycles in moderate to good yields. Their structures were confirmed by IR, ¹H NMR, ¹³C NMR and HRMS. Furthermore, this method has the advantages of mild reaction conditions, broad substrates scope and environmentally benign. Notably, the current methodology could also be conveniently applied to the synthesis of thioarylated naturally occurring biologically active frameworks.

Key words: N-iodosuccinimide, ionic liquids, imidazo[1,2-a]pyridines, disulfides, arylsulfenylation

Cite this article

An Yanni, Li Jianxiao, Li Meng, Li Chunsheng, Yang Shaorong. N-Iodosuccinimide-Promoted Regioselective Arylsulfenylation of Imidazo[1,2-a]pyridines with Disulfides[J]. Chin. J. Org. Chem., 2017, 37(3): 720-725.

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N-碘代丁二酰亚胺促进的咪唑并[1,2-a]吡啶衍生物的芳烃硫基化反应

N-Iodosuccinimide-Promoted Regioselective Arylsulfenylation of Imidazo[1,2-a]pyridines with Disulfides

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