Chemical Constituents from the Cultures of Fungus Xylaria polymorpha

doi:10.6023/cjoc201612039

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (4): 1033-1039.DOI: 10.6023/cjoc201612039 Previous Articles Next Articles

NOTE

多形炭角菌Xylaria polymorpha菌丝发酵的次级代谢产物研究

杨宁宁^a,b, 孔凡栋^b, 马青云^b, 黄圣卓^b, 罗都强^c, 周丽曼^b, 戴好富^b, 郁志芳^a, 赵友兴^b

a. 南京农业大学食品科技学院南京 210095;
b. 中国热带农业科学院热带生物技术研究所海口 571101;
c. 河北大学生命科学学院教育部药物化学与分子诊断教育部重点实验室保定 071002

收稿日期:2016-12-12 修回日期:2016-12-22 发布日期:2017-01-04
通讯作者: 郁志芳, 赵友兴 E-mail:yuzhifang@njau.edu.cn;zhaoyouxing@itbb.org.cn
基金资助:
公益性行业（农业）科研专项（No.201303117）、中央级公益性科研院所基本科研业务费（No.1630052016008）、海南省自然科学基金面上（No.20153143）资助项目.

Chemical Constituents from the Cultures of Fungus Xylaria polymorpha

Yang Ningning^a,b, Kong Fandong^b, Ma Qingyun^b, Huang Shengzhuo^b, Luo Duqiang^c, Zhou Liman^b, Dai Haofu^b, Yu Zhifang^a, Zhao Youxing^b

a. College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095;
b. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101;
c. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, College of Life Science, Baoding 071002

Received:2016-12-12 Revised:2016-12-22 Published:2017-01-04
Contact: 10.6023/cjoc201612039 E-mail:yuzhifang@njau.edu.cn;zhaoyouxing@itbb.org.cn
Supported by:
Project supported by the Special Fund for Agro-Scientific Research in the Public Interest (No. 201303117), the Fundamental Scientific Research Funds for Chinese Academy of Tropical Agricultural Sciences (No. 1630052016008) and the Natural Science Foundation of Hainan Province (No. 20153143).

1. Chemical Constituents from the Cultures of Fungus Xylaria polymorpha.PDF(1534KB)

Abstract

Totally 21 compounds were isolated from the EtOAc extract of fermentation broth of fungus Xylaria polymorpha (Pers.: Fr.) Grer, including two new drimane-type sesquiterpenoids named polymorphines A and B (1~2) and one new phenyloxolane compound named 2-methyl-2-(4-hydroxymethylphenyl) oxolane (3), together with 18 known compounds 4~21. The structures of these compounds were elucidated by NMR and single-crystal X-ray diffraction analysis. Compound 2 exhibited anti-acetylcholinesterase and α-glucosidase inhibitory activities. Moreover, compound 3 showed moderate inhibitory activitiy against the nematode Panagrellus redivivus with mortality ratio of 59.6% at 2.5 mg/mL.

Key words: Xylaria polymorpha, sesquiterpene, AChE inhibitory activity, α-glucosidase inhibitory activity, anti-nematode activity

Cite this article

Yang Ningning, Kong Fandong, Ma Qingyun, Huang Shengzhuo, Luo Duqiang, Zhou Liman, Dai Haofu, Yu Zhifang, Zhao Youxing. Chemical Constituents from the Cultures of Fungus Xylaria polymorpha[J]. Chin. J. Org. Chem., 2017, 37(4): 1033-1039.

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多形炭角菌Xylaria polymorpha菌丝发酵的次级代谢产物研究

Chemical Constituents from the Cultures of Fungus Xylaria polymorpha

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