Construction of Carbazoles by Palladium-Catalyzed Direct Cross-Coupling of Indoles with in situ Generated Aryl Vinyl Ketones

doi:10.6023/cjoc201705014

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (10): 2655-2662.DOI: 10.6023/cjoc201705014 Previous Articles Next Articles

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钯催化取代吲哚与苯丙酮类化合物的直接偶联构筑咔唑衍生物

周全龙^a,b, 朱昌垒^a, 吴戈^a, 张远飞^a, 张敏^a, 苏伟平^a,b

a 中国科学院福建物质结构研究所结构化学国家重点实验室福州 350002;
b 福建师范大学材料科学与工程学院福州 350007

收稿日期:2017-05-08 修回日期:2017-07-06 发布日期:2017-08-11
通讯作者: 张敏, 苏伟平 E-mail:zhangmin@fjirsm.ac.cn;wpsu@fjirsm.ac.cn
基金资助:
国家自然科学基金（Nos.21431008，21332001，21602221，u1505242）资助项目.

Construction of Carbazoles by Palladium-Catalyzed Direct Cross-Coupling of Indoles with in situ Generated Aryl Vinyl Ketones

Zhou Quanlong^a,b, Zhu Changlei^a, Wu Ge^a, Zhang Yuanfei^a, Zhang Min^a, Su Weiping^a,b

a State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002;
b College of Materials Science and Engineering, Fujian Normal University, Fuzhou 350007

Received:2017-05-08 Revised:2017-07-06 Published:2017-08-11
Contact: 10.6023/cjoc201705014 E-mail:zhangmin@fjirsm.ac.cn;wpsu@fjirsm.ac.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos.21431008,21332001,21602221,u1505242).

The synthesis of carbazoles via Pd-catalyzed direct cross-coupling of indoles with in situ generated aryl vinyl ketones by using statured ketones as the olefins source is described. This protocol obviates the need for additional preparation steps of aryl vinyl ketones and therefore opens up a new door to synthesis of carbazoles in an atom-and step-economical fashion.

Key words: palladium-catalyzed, dehydrogenation, carbazoles, C—H functionalization, cross-coupling

Cite this article

Zhou Quanlong, Zhu Changlei, Wu Ge, Zhang Yuanfei, Zhang Min, Su Weiping. Construction of Carbazoles by Palladium-Catalyzed Direct Cross-Coupling of Indoles with in situ Generated Aryl Vinyl Ketones[J]. Chin. J. Org. Chem., 2017, 37(10): 2655-2662.

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钯催化取代吲哚与苯丙酮类化合物的直接偶联构筑咔唑衍生物

Construction of Carbazoles by Palladium-Catalyzed Direct Cross-Coupling of Indoles with in situ Generated Aryl Vinyl Ketones

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