Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (3): 710-714.DOI: 10.6023/cjoc201709008 Previous Articles     Next Articles



邵泰明a,b, 李小宝a, 祁翠翠a, 陈光英a, 宋小平a, 韩长日a,b, 郑彩娟a   

  1. a 海南师范大学热带药用植物化学教育部重点实验室 海南师范大学化学与化工学院 海口 571158;
    b 海南省药食同源植物资源重点实验室 海南科技职业学院化学与材料工程学院 海口 571126
  • 收稿日期:2017-09-06 修回日期:2017-10-12 发布日期:2017-11-15
  • 通讯作者: 宋小平,;韩长日,;
  • 基金资助:


Chemical Constituents of Isoflavonoids from Roots of Ficus auriculata

Shao Taiminga,b, Li Xiaobaoa, Qi Cuicuia, Chen Guangyinga, Song Xiaopinga, Han Changria,b, Zheng Caijuana   

  1. a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571127;
    b Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, School of Chemical and Material Engineering, Hainan Institute of Science and Technology, Haikou 571126
  • Received:2017-09-06 Revised:2017-10-12 Published:2017-11-15
  • Contact: 10.6023/cjoc201709008;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 81360478, 21362009), the International S&T Cooperation Program of China (No. 2014DFA40850), the Hainan Special Project for Traditional Chinese Medicine Modernization (No. 2015ZY19), Key Research and Development Project of Hainan Province (No. ZDYF2016139), the Natural Science Foundation of Hainan Province (No. 217177), the Youth Foundation of Hainan Institute of Science and Technology (No. HKYZQJ2014-07), the Hainan Province Innovation Research Project of Graduate Students (No. Hyb2017-33).

Five isoflavonoids were isolated from the roots of the Ficus auriculata by means of silica gel column, HPLC and other chromatography methods. By using spectroscopic techniques including NMR, IR and UV, their structures were identified as 5,7,4'-trihydroxy-8-(1-hydroxy-2,3-epoxy-3-methylbutyl)isoflavone (1), 5,7,4'-trihydroxy-3'-(2,6,7-trihydroxy-3-methylene-7-methyloctyl)isoflavone (2), 5,7,4'-trihydroxy-6-[(S)-2,3-dihydroxy-3-methylbutyl]isoflavone (3), 5,7,4'-trihydroxy-6-pre-nylisoflavone (4), and 5,7,4'-trihydroxy-3'-prenylisoflavone (5). Compounds 1 and 2 were new isoflavonoids. All compounds were evaluated for their anti osteoporosis activities in vitro. Compounds 4 and 5 showed moderate proliferation function of primary osteoblasts in 100 μmol/L.

Key words: Ficus auriculata, chemical constituent, isoflavone, anti osteoporosis activity