Research on the Semi-synthesis of Pectolinarin from Scutellarin

doi:10.6023/cjoc201807051

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (2): 412-418.DOI: 10.6023/cjoc201807051 Previous Articles Next Articles

ARTICLE

灯盏花乙素半合成柳穿鱼叶苷研究

颜世强, 谢明现, 王玉杰, 李英霞

复旦大学药学院上海 201203

收稿日期:2018-07-27 修回日期:2018-09-14 发布日期:2018-10-12
通讯作者: 李英霞 E-mail:liyx417@fudan.edu.cn
基金资助:
国家自然科学基金（No.81773576）资助项目.

Research on the Semi-synthesis of Pectolinarin from Scutellarin

Yan Shiqiang, Xie Mingxian, Wang Yujie, Li Yingxia

School of Pharmacy, Fudan University, Shanghai 201203

Received:2018-07-27 Revised:2018-09-14 Published:2018-10-12
Contact: 10.6023/cjoc201807051 E-mail:liyx417@fudan.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (No. 81773576).

1. Research on the Semi-synthesis of Pectolinarin from Scutellarin.PDF(3252KB)

Abstract

As the representative flavonoid and flavonoid glycoside of Chinese medicine Cirsium japonicum, pectolinarigenin and pectolinarin have important bioactivities. In this paper, the efficient semi-synthesis of pectolinarigenin had been achieved starting from commercially available scutellarin via a linear reaction sequence of 3 steps with the overall yield of 69.5%, wherein carboxyl esterification, selective hydroxy protecting, and glycosidic bond hydrolyzation were used. Afterwards, the chemical synthesis of pectolinarin had been accomplished by the glycosylation of pectolinarigenin and benzobromorutinose.

Key words: scutellarin, pectolinarigenin, pectolinarin, flavonoids, semi-synthesis

Cite this article

Yan Shiqiang, Xie Mingxian, Wang Yujie, Li Yingxia. Research on the Semi-synthesis of Pectolinarin from Scutellarin[J]. Chin. J. Org. Chem., 2019, 39(2): 412-418.

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灯盏花乙素半合成柳穿鱼叶苷研究

Research on the Semi-synthesis of Pectolinarin from Scutellarin

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