Recent Advances in the Synthesis of CF3-Substituted Triazoles and Tetrazoles

doi:10.6023/cjoc201808007

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (1): 109-116.DOI: 10.6023/cjoc201808007 Previous Articles Next Articles

Special Issue: 庆祝陈庆云院士九十华诞

Reviews

三氟甲基三氮唑及四氮唑化合物的合成研究进展

张发光, 彭星, 马军安

天津大学理学院化学系天津市分子光电科学重点实验室天津化学化工协同创新中心天津 300072

收稿日期:2018-08-07 修回日期:2018-09-14 发布日期:2018-10-12
通讯作者: 张发光, 马军安 E-mail:zhangfg1987@tju.edu.cn;majun_an68@tju.edu.cn
基金资助:
国家自然科学基金（Nos.21472137，21532008，21772142）和国家重点基础研究发展计划（973计划，No.20014CB745100）资助项目.

Recent Advances in the Synthesis of CF₃-Substituted Triazoles and Tetrazoles

Zhang Faguang, Peng Xing, Ma Jun'an

Tianjin Key Laboratory of Molecular Optoelectronic Sciences, and Tianjin Collaborative Innovation Center of Chemical Science & Engineering, Department of Chemistry, Tianjin University, Tianjin 300072

Received:2018-08-07 Revised:2018-09-14 Published:2018-10-12
Contact: 10.6023/cjoc201808007 E-mail:zhangfg1987@tju.edu.cn;majun_an68@tju.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21472137, 21532008, 21772142) and the National Basic Research Program of China (973 Program, No. 2014CB745100).

Trifluoromethylated triazoles and tetrazoles have emerged as increasingly important heterocycles in pharmaceuticals, agrochemicals, catalysis, and materials. As a consequence, great attention has been paid to the efficient synthesis of these valuable CF₃-containing molecules. Herein, the advances in the past decade towards the synthesis of CF₃-substituted triazoles and tetrazoles are summarized. The remarkable progress in the utilization of versatile CF₃-functionalized building blocks including CF₃-containing alkynes, CF₃-containing carbonyl compounds, CF₃-containing pyrones and trifluorodiazoethane (CF₃CHN₂) is demonstrated accordingly.

Key words: trifluoromethyl group, triazole, tetrazole, fluorine-containing heterocycle, cycloaddition

Cite this article

Zhang Faguang, Peng Xing, Ma Jun'an. Recent Advances in the Synthesis of CF₃-Substituted Triazoles and Tetrazoles[J]. Chin. J. Org. Chem., 2019, 39(1): 109-116.

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三氟甲基三氮唑及四氮唑化合物的合成研究进展

Recent Advances in the Synthesis of CF₃-Substituted Triazoles and Tetrazoles

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