Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (1): 209-214.DOI: 10.6023/cjoc201907041 Previous Articles     Next Articles

巴戟天内生真菌Trichoderma spirale A725中两个新的聚酮类化合物

陈书帅a,b, 刘洪新b, 刘昭明b, 李赛妮b, 陈玉婵b, 李浩华b, 李冬利a, 章卫民b   

  1. a 五邑大学生物科技与大健康学院 广东江门 529020;
    b 广东省微生物研究所 广东省科学院 华南应用微生物国家重点实验室 广东省菌种保藏与应用重点实验室 广东省微生物应用新技术公共实验室 广州 510075
  • 收稿日期:2019-07-26 修回日期:2019-09-10 发布日期:2019-09-25
  • 通讯作者: 章卫民, 李冬利;
  • 基金资助:

Two New Polyketide Compounds from the Endophytic Fungus Trichoderma spirale A725 of Morinda officinalis

Chen Shushuaia,b, Liu Hongxinb, Liu Zhaomingb, Li Sainib, Chen Yuchanb, Li Haohuab, Li Donglia, Zhang Weiminb   

  1. a School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529020;
    b State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070
  • Received:2019-07-26 Revised:2019-09-10 Published:2019-09-25
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 31600271), the Guangdong Provincial Project for Science and Technology (No. 2107A020211023), and the Pearl River Science and Technology New Star Fund of Guangzhou City (No. 201806010080).

Six polyketides were isolated from the fermentation broth of an endophytic fungus Trichoderma spirale A725 of the medicinal plant Morinda officinalis by silica gel, reversed phase silica column chromatography, sephadex LH-20 and high performance preparative liquid chromatography. Their structures were elucidated to be 6-hydroxy-4-isopropyl-1,8-dimethyl-spiro[4.5]deca-1,8-dien-7-one (1), 2-hydroxy-2,5-dimethyl-7-oxo-5,7-dihydro-2H-furo[3,4-b]pyran-4-carboxylicacid (2), 3-ethyl-4-hydroxy-6-methyl-2H-pyran-2-one (3), harzialactone A (4), 3-hydroxy-5-(4-hydroxybenzyl)dihydrofuran-2(3H)-one (5), and 4-acetyl-3-hydroxy-6-methyl-pyran-2-one (6) on the basis of extensive spectral analysis. Among them, compounds 1 and 2 were new compounds, and compound 3 was a new natural product. Moreover, the cytotoxicities of compounds 1~6 were evaluated against four cancer cell lines (Hep G-2, MCF-7, SF-268 and A549). However, none of them exhibited cytotoxic activity against the tested tumor cells.

Key words: Morinda officinalis, endophyte fungus, Trichoderma spirale, polyketide