Two New Polyketide Compounds from the Endophytic Fungus Trichoderma spirale A725 of Morinda officinalis

doi:10.6023/cjoc201907041

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (1): 209-214.DOI: 10.6023/cjoc201907041 Previous Articles Next Articles

巴戟天内生真菌Trichoderma spirale A725中两个新的聚酮类化合物

陈书帅^a,b, 刘洪新^b, 刘昭明^b, 李赛妮^b, 陈玉婵^b, 李浩华^b, 李冬利^a, 章卫民^b

a 五邑大学生物科技与大健康学院广东江门 529020;
b 广东省微生物研究所广东省科学院华南应用微生物国家重点实验室广东省菌种保藏与应用重点实验室广东省微生物应用新技术公共实验室广州 510075

收稿日期:2019-07-26 修回日期:2019-09-10 发布日期:2019-09-25
通讯作者: 章卫民, 李冬利 E-mail:wmzhang@gdim.cn;wyuchemldl@wyu.edu.cn
基金资助:
国家自然科学基金（No.31600271）、广东省科技计划（No.2107A020211023）和广州市珠江科技新星（No.201806010080）资助项目.

Two New Polyketide Compounds from the Endophytic Fungus Trichoderma spirale A725 of Morinda officinalis

Chen Shushuai^a,b, Liu Hongxin^b, Liu Zhaoming^b, Li Saini^b, Chen Yuchan^b, Li Haohua^b, Li Dongli^a, Zhang Weimin^b

a School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529020;
b State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070

Received:2019-07-26 Revised:2019-09-10 Published:2019-09-25
Supported by:
Project supported by the National Natural Science Foundation of China (No. 31600271), the Guangdong Provincial Project for Science and Technology (No. 2107A020211023), and the Pearl River Science and Technology New Star Fund of Guangzhou City (No. 201806010080).

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Abstract

Six polyketides were isolated from the fermentation broth of an endophytic fungus Trichoderma spirale A725 of the medicinal plant Morinda officinalis by silica gel, reversed phase silica column chromatography, sephadex LH-20 and high performance preparative liquid chromatography. Their structures were elucidated to be 6-hydroxy-4-isopropyl-1,8-dimethyl-spiro[4.5]deca-1,8-dien-7-one (1), 2-hydroxy-2,5-dimethyl-7-oxo-5,7-dihydro-2H-furo[3,4-b]pyran-4-carboxylicacid (2), 3-ethyl-4-hydroxy-6-methyl-2H-pyran-2-one (3), harzialactone A (4), 3-hydroxy-5-(4-hydroxybenzyl)dihydrofuran-2(3H)-one (5), and 4-acetyl-3-hydroxy-6-methyl-pyran-2-one (6) on the basis of extensive spectral analysis. Among them, compounds 1 and 2 were new compounds, and compound 3 was a new natural product. Moreover, the cytotoxicities of compounds 1~6 were evaluated against four cancer cell lines (Hep G-2, MCF-7, SF-268 and A549). However, none of them exhibited cytotoxic activity against the tested tumor cells.

Key words: Morinda officinalis, endophyte fungus, Trichoderma spirale, polyketide

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Chen Shushuai, Liu Hongxin, Liu Zhaoming, Li Saini, Chen Yuchan, Li Haohua, Li Dongli, Zhang Weimin. Two New Polyketide Compounds from the Endophytic Fungus Trichoderma spirale A725 of Morinda officinalis[J]. Chinese Journal of Organic Chemistry, 2020, 40(1): 209-214.

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巴戟天内生真菌Trichoderma spirale A725中两个新的聚酮类化合物

Two New Polyketide Compounds from the Endophytic Fungus Trichoderma spirale A725 of Morinda officinalis

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