Progress in the Synthesis of Isoxazoline Derivatives by Cycloylation of Allyl Oxime

doi:10.6023/cjoc202003056

Abstract

Isoxazoline is an important class of heterocyclic ring with a wide range of biological characteristics, which is the key structural framework of many natural products and bioactive compounds. The effective synthetic method of isoxazoline has been the subject of extensive research. In this review, the latest progress in the synthesis of various functionalized isoxazoline by allyl oxime, involving the radical oxidation/cyclization reaction in the presence of oxidants is described. These reactions are usually carried out under neutral conditions using readily available oxidants and different metals or metal-free catalysis.

Key words: isoxazoline, allyl oxime, cyclization reaction, metal catalysis

Cite this article

Liu Yingjie, Meng Jianping, Li Chen, Lin Liqing, Xu Ying. Progress in the Synthesis of Isoxazoline Derivatives by Cycloylation of Allyl Oxime[J]. Chinese Journal of Organic Chemistry, 2020, 40(9): 2742-2754.

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