Research Progress on [3+n] (n≥3) Cycloaddition of 1,3-Diploes

doi:10.6023/cjoc202005092

Abstract

Versatile heterocyclic skeletons extensively exist in structures of natural products, drug molecules and organic materials, and have been synthesized through various strategies reported in literatures. Among them, the 1,3-dipolar cycloaddition is the most impressive class to build the related heterocycles. In the past, organic chemists generally employed[3+2] cycloaddition of 1,3-dipoles to assemble five-membered rings. As modern chemistry developes, researchers further turn their attention to the[3+3],[3+4],[3+5] and[3+6] cycloadditions, to construct six-, seven-, eight- and bridge-heterocyclic compounds. At present, review articles with topics on 1,3-dipolar cycloaddition mainly focus on[3+2] cycloaddition. Herein, A topic on[3+n] (n ≥ 3) cycloaddition of 1,3-dipoles, with comments on the developed methodologies is present and the outlook in this field is proposed.

Key words: 1,3-diploar cycloaddtion, nitrone, azomethine ylide, azomethine imine, nitrile imine, nitrile oxide, nitrile ylide

Cite this article

Yue Guizhou, Liu Bo. Research Progress on [3+n] (n≥3) Cycloaddition of 1,3-Diploes[J]. Chinese Journal of Organic Chemistry, 2020, 40(10): 3132-3153.

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1,3-偶极子[3+n](n≥3)环加成反应的研究进展