Synthesis of a Type of Linear β,γ-Unsaturated α-Keto Tryptophol Ester Compounds

doi:10.6023/cjoc202005051

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (9): 2778-2787.DOI: 10.6023/cjoc202005051 Previous Articles Next Articles

一类线性β,γ-不饱和α-酮酸色醇酯类化合物的合成

余接强^a, 贾俊^b, 王兴旺^a

a 苏州大学材料与化学化工学部江苏苏州 215123;
b 苏州大学分析测试中心江苏苏州 215123

收稿日期:2020-05-19 修回日期:2020-06-22 发布日期:2020-07-09
通讯作者: 贾俊, 王兴旺 E-mail:jiajun@suda.edu.cn;wangxw@suda.edu.cn
基金资助:
国家自然科学基金（No.21971176）资助项目.

Synthesis of a Type of Linear β,γ-Unsaturated α-Keto Tryptophol Ester Compounds

Yu Jieqiang^a, Jia Jun^b, Wang Xingwang^a

a College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123;
b Analysis and Testing Center, Soochow University, Suzhou, Jiangsu 215123

Received:2020-05-19 Revised:2020-06-22 Published:2020-07-09
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21971176).

1. cjoc202005051.pdf(1913KB)

Abstract

Tryptophol derivatives are very important compounds with wide spectrum of pharmaceutical and physiological activity. Herein, the esterification reaction of trypthol and its derivatives with β,γ-unsaturated α-keto acids was reported by the use of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) and 1-hydroxybenzotriazole (HOBt) as conden-sation reagents. A series of β,γ-unsaturated α-keto trypanol ester derivatives were prepared in moderate to high yields. This method has advantages of riched functional group tolerance, readily available starting materials and easy operation.

Key words: condensation reagent, tryptophol, esterification, β,γ-unsaturated α-keto acid, β,γ-unsaturated α-keto trypanol ester

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Yu Jieqiang, Jia Jun, Wang Xingwang. Synthesis of a Type of Linear β,γ-Unsaturated α-Keto Tryptophol Ester Compounds[J]. Chinese Journal of Organic Chemistry, 2020, 40(9): 2778-2787.

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一类线性β,γ-不饱和α-酮酸色醇酯类化合物的合成

Synthesis of a Type of Linear β,γ-Unsaturated α-Keto Tryptophol Ester Compounds

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