Novel Three-Component Annulation for the Synthesis of 2,4,6-Triaryl-pyrimidines under Solvent-Free and Catalyst-Free Conditions

doi:10.6023/cjoc202005078

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (12): 4357-4363.DOI: 10.6023/cjoc202005078 Previous Articles Next Articles

无溶剂无催化剂条件下三组分一锅合成2,4,6-三芳基嘧啶衍生物的新方法

丁雨昕^a,b, 马永敏^a,b, 陈静^a

a 浙江中医药大学药学院浙江杭州 310053;
b 台州大学医药化工学院浙江台州 318000

收稿日期:2020-05-28 修回日期:2020-06-28 发布日期:2020-07-23
通讯作者: 马永敏, 陈静 E-mail:yongmin.ma@tzc.edu.cn;cjmaggie@163.com
基金资助:
浙江省自然科学基金（No.LY19H300001）、浙江中医药大学校级科研基金（No.2018ZG31）和2019年度高等学校国内访问者“教师专业发展项目”（No.FX2019020）资助项目.

Novel Three-Component Annulation for the Synthesis of 2,4,6-Triaryl-pyrimidines under Solvent-Free and Catalyst-Free Conditions

Ding Yuxin^a,b, Ma Yongmin^a,b, Chen Jing^a

a School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053;
b School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, Zhejiang 318000

Received:2020-05-28 Revised:2020-06-28 Published:2020-07-23
Supported by:
Project supported by the Natural Science Foundation of Zhejiang Province (No. LY19H300001), the Zhejiang Chinese Medicinal University Foundation (No. 2018ZG31) and the "Teacher Professional Development Project" for Domestic Visitors of Institutions of Higher Learning in 2019 (No. FX2019020).

1. cjoc202005078.pdf(5011KB)

Abstract

2,4,6-Triarylpyrimidines were synthesized via a simple, efficient, one-pot, three-component reaction from 1,3-dikeones, benzaldehydes and ammonium acetate under solvent-free and catalyst-free conditions in good to excellent yields. This "green" methodology provides an eco-friendly protocol for the construction of the pyrimidine framework.

Key words: catalyst-free, solvent-free, one-pot, three-component reaction, 2,4,6-triarylpyrimidine

Cite this article

Ding Yuxin, Ma Yongmin, Chen Jing. Novel Three-Component Annulation for the Synthesis of 2,4,6-Triaryl-pyrimidines under Solvent-Free and Catalyst-Free Conditions[J]. Chinese Journal of Organic Chemistry, 2020, 40(12): 4357-4363.

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无溶剂无催化剂条件下三组分一锅合成2,4,6-三芳基嘧啶衍生物的新方法

Novel Three-Component Annulation for the Synthesis of 2,4,6-Triaryl-pyrimidines under Solvent-Free and Catalyst-Free Conditions

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