Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (4): 1582-1590.DOI: 10.6023/cjoc202101003 Previous Articles Next Articles
ARTICLES
王榕a,b, 徐立晨a,b, 卢逸a, 姜波a,*(), 郝文娟a,*()
收稿日期:
2021-01-03
修回日期:
2021-01-23
发布日期:
2021-02-22
通讯作者:
姜波, 郝文娟
作者简介:
基金资助:
Rong Wanga,b, Lichen Xua,b, Yi Lua, Bo Jianga,*(), Wenjuan Haoa,*()
Received:
2021-01-03
Revised:
2021-01-23
Published:
2021-02-22
Contact:
Bo Jiang, Wenjuan Hao
About author:
Supported by:
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Rong Wang, Lichen Xu, Yi Lu, Bo Jiang, Wenjuan Hao. Sc(OTf)3-Catalyzed Dearomatization of Indoles for the Synthesis of 3,3'-Bisindoles[J]. Chinese Journal of Organic Chemistry, 2021, 41(4): 1582-1590.
Entry | Cat. (mol%) | Solvent | t/℃ | Yieldb/% |
---|---|---|---|---|
1 | Sc(OTf)3 (10) | 1,4-Dioxane | 80 | 78 |
2 | Sc(OTf)3 (20) | 1,4-Dioxane | 80 | 82 |
3 | Sc(OTf)3 (30) | 1,4-Dioxane | 80 | 81 |
4 | Cu(OTf)2 (20) | 1,4-Dioxane | 80 | Trace |
5 | Mg(OTf)2 (20) | 1,4-Dioxane | 80 | 57 |
6 | Sc(OTf)3 (20) | CH3CN | 80 | N.D. |
7 | Sc(OTf)3 (20) | EtOH | 80 | N.D. |
8 | Sc(OTf)3 (20) | DMF | 80 | N.D. |
9 | Sc(OTf)3 (20) | EA | 80 | Trace |
10 | Sc(OTf)3 (20) | 1,4-Dioxane | 70 | 75 |
11 | Sc(OTf)3 (20) | 1,4-Dioxane | 90 | 70 |
Sc(OTf)3 (20) | 1,4-Dioxane | 100 | 63 |
Entry | Cat. (mol%) | Solvent | t/℃ | Yieldb/% |
---|---|---|---|---|
1 | Sc(OTf)3 (10) | 1,4-Dioxane | 80 | 78 |
2 | Sc(OTf)3 (20) | 1,4-Dioxane | 80 | 82 |
3 | Sc(OTf)3 (30) | 1,4-Dioxane | 80 | 81 |
4 | Cu(OTf)2 (20) | 1,4-Dioxane | 80 | Trace |
5 | Mg(OTf)2 (20) | 1,4-Dioxane | 80 | 57 |
6 | Sc(OTf)3 (20) | CH3CN | 80 | N.D. |
7 | Sc(OTf)3 (20) | EtOH | 80 | N.D. |
8 | Sc(OTf)3 (20) | DMF | 80 | N.D. |
9 | Sc(OTf)3 (20) | EA | 80 | Trace |
10 | Sc(OTf)3 (20) | 1,4-Dioxane | 70 | 75 |
11 | Sc(OTf)3 (20) | 1,4-Dioxane | 90 | 70 |
Sc(OTf)3 (20) | 1,4-Dioxane | 100 | 63 |
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