Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (9): 3617-3624.DOI: 10.6023/cjoc202103059 Previous Articles Next Articles
ARTICLES
王胜辉a, 关永风b, 刘秀娟c, 原信颖c, 蔚广曦a, 李银茹a, 张雁冰c, 宋健a,c,*(), 李雯b,c,*(), 张赛扬a,c,*()
收稿日期:
2021-03-30
修回日期:
2021-05-25
发布日期:
2021-06-29
通讯作者:
宋健, 李雯, 张赛扬
作者简介:
基金资助:
Shenghui Wanga, Yongfeng Guanb, Xiujuan Liuc, Xinying Yuanc, Guangxi Yua, Yinru Lia, Yanbing Zhangc, Jian Songa,c(), Wen Lib,c(), Saiyang Zhanga,c()
Received:
2021-03-30
Revised:
2021-05-25
Published:
2021-06-29
Contact:
Jian Song, Wen Li, Saiyang Zhang
About author:
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Shenghui Wang, Yongfeng Guan, Xiujuan Liu, Xinying Yuan, Guangxi Yu, Yinru Li, Yanbing Zhang, Jian Song, Wen Li, Saiyang Zhang. Design, Synthesis and Anticancer Activity Studies of Novel Quinoline-Indole Derivatives[J]. Chinese Journal of Organic Chemistry, 2021, 41(9): 3617-3624.
Compound | IC50/(μmol•L–1)a | ||
---|---|---|---|
MGC-803 | Kyse450 | HCT-116 | |
9a | 3.91±0.22 | 3.27±0.18 | 3.11±0.16 |
9b | 0.58±0.01 | 0.68±0.03 | 0.59±0.04 |
9c | 4.10±0.21 | 5.17±0.53 | 8.23±0.42 |
9d | 2.86±0.19 | 6.78±1.04 | 6.01±0.37 |
9e | 4.34±0.44 | 4.68±0.24 | 5.91±0.38 |
9f | 7.00±0.82 | 5.27±0.34 | 11.1±1.41 |
9g | 2.42±0.12 | 3.04±0.23 | 2.87±0.21 |
9h | 1.16±0.05 | 1.40±0.12 | 1.71±0.19 |
9i | >20 | >20 | >20 |
9j | 4.58±0.25 | 6.57±0.21 | 5.06±0.33 |
5-Fu | 6.82±0.82 | 17.4±1.23 | 14.2±1.22 |
Compound | IC50/(μmol•L–1)a | ||
---|---|---|---|
MGC-803 | Kyse450 | HCT-116 | |
9a | 3.91±0.22 | 3.27±0.18 | 3.11±0.16 |
9b | 0.58±0.01 | 0.68±0.03 | 0.59±0.04 |
9c | 4.10±0.21 | 5.17±0.53 | 8.23±0.42 |
9d | 2.86±0.19 | 6.78±1.04 | 6.01±0.37 |
9e | 4.34±0.44 | 4.68±0.24 | 5.91±0.38 |
9f | 7.00±0.82 | 5.27±0.34 | 11.1±1.41 |
9g | 2.42±0.12 | 3.04±0.23 | 2.87±0.21 |
9h | 1.16±0.05 | 1.40±0.12 | 1.71±0.19 |
9i | >20 | >20 | >20 |
9j | 4.58±0.25 | 6.57±0.21 | 5.06±0.33 |
5-Fu | 6.82±0.82 | 17.4±1.23 | 14.2±1.22 |
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