Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (9): 3239-3245.DOI: 10.6023/cjoc202301023 Previous Articles     Next Articles

Special Issue: 有机氟化学虚拟合辑


岁丹丹a, 岑南楠a, 龚若蕖a, 陈阳a, 陈文博a,b,*()   

  1. a 上海电力大学环境与化学工程学院 上海市电力材料防护与新材料重点实验室 上海 200090
    b 中国科学院上海有机化学研究所 中国科学院能量调控材料重点实验室 上海 200032
  • 收稿日期:2023-01-29 修回日期:2023-05-07 发布日期:2023-05-23
  • 基金资助:
    上海市自然科学基金(20ZR1471600); 上海市科学技术委员会(19DZ2271100); 中国科学院能量调控材料重点实验室开放基金(ORFP2020-06)

Supporting-Electrolyte-Free Electrochemical Synthesis of Trifluoromethylated Oxindoles in Continuous Flow

Dandan Suia, Nannan Cena, Ruoqu Gonga, Yang Chena, Wenbo Chena,b()   

  1. a Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power, College of Environmental and Chemical Engineering, Shanghai University of Electric Power, Shanghai 200090
    b CAS Key Laboratory of Energy Regulation Materials, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2023-01-29 Revised:2023-05-07 Published:2023-05-23
  • Contact: E-mail:
  • Supported by:
    Natural Science Foundation of Shanghai(20ZR1471600); Science and Technology Commission of Shanghai Municipality(19DZ2271100); Open Research Fund Program of CAS Key Laboratory of Energy Regulation Materials(ORFP2020-06)

A supporting electrolyte-free method for the electrochemical synthesis of trifluoromethylated oxindoles in conti- nuous flow was developed. Various N-arylacrylamides reacted with CF3SO2NHNHBoc smoothly to provide the corresponding products in moderate yields. The reaction scale-up was easily realized without changing the reaction conditions, which showed the application potential of continuous flow electrochemical synthesis.

Key words: trifluoromethyl, electrochemical synthesis, continuous flow, oxindole, green chemistry