Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (1): 85-99.DOI: 10.6023/cjoc202107051 Previous Articles     Next Articles

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炔酰胺合成方法研究进展

赵永丽a, 涂永良a, 蔡明中a, 赵军锋b,*()   

  1. a 江西师范大学化学化工学院 南昌 330022
    b 广州医科大学药学院 广州 511436
  • 发布日期:2021-09-08
  • 通讯作者: 赵军锋
  • 基金资助:
    国家自然科学基金(21778025); 国家自然科学基金(91853114)

Recent Advances in the Synthesis of Ynamides

Yongli Zhaoa, Yongliang Tua, Mingzhong Caia, Junfeng Zhaob()   

  1. a College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022
    b School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436
  • Published:2021-09-08
  • Contact: Junfeng Zhao
  • Supported by:
    National Natural Science Foundation of China(21778025); National Natural Science Foundation of China(91853114)

Ynamides are a class of special ynamines bearing an electron-withdrawing group on the nitrogen atom. The electron-withdrawing group endows ynamides an optimal balance between the stability and activity, and thus enabling ynamides to be versatile synthons widely used in organic synthetic chemistry. The ynamide chemistry has witnessed a rapid development over the past two decades. As a consequence, its synthetic methods have attracted widespread attention. In this context, the recent advances in the synthesis of ynamides are reviewed herein. According to the structure of the main starting materials, the contents are classified as the synthesis with haloenamides, alkynes or its derivatives, and dihalo-substituted alkenes. The representative mechanisms are also discussed.

Key words: ynamide, electron-withdrawing group, internal ynamide, terminal ynamide