Synthesis and Hybridizing Activity of Novel Chemical Hybridizing Agent Pyridazinone Derivatives

Chinese Journal of Organic Chemistry ›› 2004, Vol. 24 ›› Issue (6): 645-649. Previous Articles Next Articles

新型化学杂交剂哒嗪酮衍生物的合成及其对小麦去雄活性研究

齐传民^*,a, 陈万义^b, 杨凌春^a, 蒋明亮^b

^a北京师范大学化学系北京 100875
^b中国农业大学应用化学研究所北京 100094

收稿日期:2002-08-30 修回日期:2003-12-28 接受日期:2003-12-28 发布日期:2022-09-21
通讯作者: ^*E-mail: qicmin@etang.com
基金资助:
国家自然科学基金(No. 29802001)和博士后基金资助项目.

Synthesis and Hybridizing Activity of Novel Chemical Hybridizing Agent Pyridazinone Derivatives

QI, Chuan-Min^*,a, CHEN, Wan-Yi^b, YANG, Ling-Chun^a, JIANG, Ming-Liang^b

^a Department of Chemistry, Beijing Normal University, Beijing 100875
^b Department of Applied Chemistry, Chinese Agricultural University, Beijing 100094

Received:2002-08-30 Revised:2003-12-28 Accepted:2003-12-28 Published:2022-09-21

Abstract

A series of novel latent chemical hybridizing agent pyridazinone derivatives were synthesized from 1,4-dihydro-3-carboxyl-pyridazin-4-one compounds and aminothiourea, hydrazine, phenylhydrazine respectively by cyclization, where 1,4-dihydro-3-carboxyl-pyridazin-4-one compounds were obtained from the various arylamine diazonium salt and pyronone by coupling reaction. It is the first time to obtain five pyridazin-4-on-3-yl aminothiazole and five pyrazolono[3,4c]pyridazine derivatives. Furthermore, the derivatives can be used as latent chemical hybridizing agents, which has been confirmed and discussed here. In large doses, pyridazin-4-on-3-yl aminothiazole hydrochloride salts had hybridizing activity and percent sterility of them was 99% in 2100 g/ha.

Key words: pyridazine, pyridazinone, aminothiabiazole, pyrazolone

Cite this article

QI, Chuan-Min, CHEN, Wan-Yi, YANG, Ling-Chun, JIANG, Ming-Liang. Synthesis and Hybridizing Activity of Novel Chemical Hybridizing Agent Pyridazinone Derivatives[J]. Chinese Journal of Organic Chemistry, 2004, 24(6): 645-649.

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新型化学杂交剂哒嗪酮衍生物的合成及其对小麦去雄活性研究

Synthesis and Hybridizing Activity of Novel Chemical Hybridizing Agent Pyridazinone Derivatives

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