Lignanolides with Antioxidant Activity from the Stems of Dracaena angustifolia

doi:10.6023/cjoc202212010

Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (8): 2968-2972.DOI: 10.6023/cjoc202212010 Previous Articles Next Articles

长花龙血树茎中抗氧化活性的木脂素类成分研究

赵婷^a^,^b,†, 农旭华^a^,^b,†, 王佳莉^a^,^b, 许宽毓^a^,^b, 唐敏敏^a^,^b^,^c, 易继凌^a^,^b, 韩长日^d, 陈光英^a^,^b^,^*()

a 海南师范大学化学与化工学院热带药用资源化学教育部重点实验室海口 571158
b 海南师范大学化学与化工学院热带药用植物化学海南省重点实验室海口 571158
c 中国热带农业科学院椰子研究所海南文昌 571339
d 海南科技职业大学药食同源植物资源海南省重点实验室海口 571126

收稿日期:2022-12-08 修回日期:2023-03-17 发布日期:2023-04-07
作者简介:
†共同第一作者
基金资助:
国家自然科学基金(41866005); 国家自然科学基金(41606100); 海南省重点科技计划(ZDKJ202008); 海南省院士创新平台(YSPTZX202030); 以及海南省自然科学基金(221RC1054)

Lignanolides with Antioxidant Activity from the Stems of Dracaena angustifolia

Ting Zhao^a^,^b,†, Xuhua Nong^a^,^b,†, Jiali Wang^a^,^b, Kuanyu Xu^a^,^b, Minmin Tang^a^,^b^,^c, Jiling Yi^a^,^b, Changri Han^d, Guangying Chen^a^,^b()

a Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Enginneeering, Hainan Normal University, Haikou 571158
b Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
c Coconut Research Institute of Chinese Academy of Tropical Agricultural Sciences, Wenchang, Hainan 571339
d Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, Hainan Vocational |University of Science and Technology, Haikou 571126

Received:2022-12-08 Revised:2023-03-17 Published:2023-04-07
Contact: *E-mail: chgying123@163.com
About author:
†The authors contributed equally to this work
Supported by:
The National Natural Science Foundation of China(41866005); The National Natural Science Foundation of China(41606100); The Key Science and Technology Program of Hainan Province(ZDKJ202008); The Innovation Platform for Academicians of Hainan Province(YSPTZX202030); The Hainan Provincial Natural Science Foundation(221RC1054)

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Abstract

A new lignanolide given a trivial name angudracanolide A (1), together with three known lignans 2~4 and three known phenylpropanoids 5~7, was isolated from the stems of Dracaena angustifolia. The complete structure of new compound was elucidated by analysis of spectroscopic data and quantum chemistry calculations. Compounds 1~4 showed obvious antioxidant activity with IC₅₀ values of 15, 19, 25, 30 mmol/L, respectively by comparing the standard trolox with a IC₅₀ value of 45 mmol/L.

Key words: Dracaena angustifolia, lignan, antioxidant activity

Cite this article

Ting Zhao, Xuhua Nong, Jiali Wang, Kuanyu Xu, Minmin Tang, Jiling Yi, Changri Han, Guangying Chen. Lignanolides with Antioxidant Activity from the Stems of Dracaena angustifolia[J]. Chinese Journal of Organic Chemistry, 2023, 43(8): 2968-2972.

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Fig. & Tab. 4

Figure 1. Chemical constituents from Dracaena angustifolia

Figure 2. Key HMBC 1H-1H COSY and NOESY correlations for compound 1

Figure 3. Comparison of the calculated and experimental ECD spectra for compound 1

Compd.	IC₅₀/(mmol•L^－1)
1	15
2	19
3	25
4	30
5	>50
6	>50
7	>50
Trolox	45

Table 2. Antioxidant activity of compounds 1~7

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长花龙血树茎中抗氧化活性的木脂素类成分研究

Lignanolides with Antioxidant Activity from the Stems of Dracaena angustifolia

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