Chinese Journal of Organic Chemistry ›› 2025, Vol. 45 ›› Issue (6): 2171-2180.DOI: 10.6023/cjoc202409040 Previous Articles     Next Articles

ARTICLES

HCF2SO2Na: 一种作为胺的硫代甲酰化试剂的新应用

胡春洋, Yasir Mumtaz, Khan Jahangir, 王雷秉, 蒋绿齐*()   

  1. 南京理工大学化学与化工学院 南京 210094
  • 收稿日期:2024-09-27 修回日期:2024-12-05 发布日期:2025-01-03
  • 通讯作者: 蒋绿齐
  • 作者简介:

    共同第一作者.

  • 基金资助:
    国家自然科学基金(22108124)

HCF2SO2Na: a New Application as a Thioformylation Reagent for Amines

Chunyang Hu, Yasir Mumtaz, Khan Jahangir, Leibing Wang, Lvqi Jiang*()   

  1. School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094
  • Received:2024-09-27 Revised:2024-12-05 Published:2025-01-03
  • Contact: Lvqi Jiang
  • About author:

    The authors contributed equally to this work.

  • Supported by:
    National Natural Science Foundation of China(22108124)

A new application of HCF2SO2Na as a thiocarbonylation reagent was developed. The reagent is capable of interacting with amine molecules after reduction by Ph3P to achieve efficient synthesis of thioformamide compounds. The method is highly selective, and the reaction system is suitable for all kinds of primary and secondary amine substrates. The key to the successful realization of this reaction lies in the in situ generation of thioformyl fluoride (HCSF) under the reduction conditions of HCF2SO2Na. This strategy provides a new solution for the synthesis of thioformamides, which will effectively promote the application of this kind of substances in the synthesis.

Key words: HCF2SO2Na, reductive, thioformylation, amine