Chinese Journal of Organic Chemistry 2025, 45(6)

- About the Cover:
  
  A double defluorinative alkoxylation of gem-difluorinated cyclopropanes with alcohols for the synthesis of cyclopropanone ketals is reported by Che, Jiang, Yang, Hu and Xia on 2222. The reaction is elucidated to proceed via elimination and addition other than direct substitution based on the mechanistic studies. This new reaction model provides inspiration for the conversion of C―F bonds in small rings.
- About the Cover:
  
  Recent advances in cephalotane diterpenoid total synthesis are reviewed by Ding, Zhang, Zhang and Deng on page 2048. The discussion highlights key methodological breakthroughs while critically analyzing their application, and provides insightful perspectives on potential therapeutic applications of this intriguing class of com-pounds.
- About the Cover:
  
  The recent progress on transition-metal-catalyzed asym- metric carbonylative C—O, C—N, C—C and C—S cross-coupling reactions by using various alcohols, amines, boronic acids, and thiols as coupling partners under CO atmosphere or in the presence of CO surrogate is reported by Su, Yang, Yan, Jiang, Chen, Zheng and Liu on page 2007.
- About the Cover:
  
  Chiral phosphoric acids (CPA) have been widely ack- nowledged as versatile chiral organocatalysts since it was first discovered in 2004, finding application in catalyzing diverse asymmetric reactions. A comprehen- sive overview of recent advances in CPA-catalyzed asymmetric electrophilic amination reactions using di- fferent N-electrophilic reagents, including azo reagents, aryldiazonium salts, and imine derivatives, is provided by Tang and Yang on page 1785.
2025, 45(6)

25 June 2025
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REVIEWS ARTICLES HIGHLIGHTS

REVIEWS

Advances on Chiral Phosphoric Acid Catalyzed Asymmetric Electrophilic Amination Reactions

Mengyao Tang, Xiaoyu Yang

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 1785-1818 DOI: 10.6023/cjoc202409028

Abstract( 380) HTML( 57) PDF(1210KB)( 363 )

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Recent Advances in Electrophotochemical Transition Metal Catalysis

Yan Yao, Niankai Fu

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 1819-1837 DOI: 10.6023/cjoc202409038

Abstract( 337) HTML( 20) PDF(1068KB)( 416 )

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Recent Progress on Catalytic Synthesis of Enantioenriched α-Arylated Ketones

Yiming Du, Junsong Jia, Yulong Li, Wei Shu

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 1838-1870 DOI: 10.6023/cjoc202408031

Abstract( 516) HTML( 25) PDF(1548KB)( 652 )

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Recent Advances in Ni-Catalyzed Migratory Cross-Coupling Reactions

Haichen Ma, Junqian Zhou, Jiali Wang, You Wang, Shaolin Zhu

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 1871-1904 DOI: 10.6023/cjoc202408035

Abstract( 529) HTML( 17) PDF(1593KB)( 741 )

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Recent Progress on the Construction of C(sp²)—C(sp³) Bonds via Photoredox/Nickel Dual Catalysis

Genwei Gao, Zhen Li, Yan Li, Xi Lu

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 1905-1919 DOI: 10.6023/cjoc202504001

Abstract( 397) HTML( 23) PDF(928KB)( 367 )

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Progress in the Construction of Functionalized Derivatives Based on Dihydropyran Skeleton Modification

Zeqi Wei, Xinhao Sun, Sirui Li, Wangze Song

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 1920-1945 DOI: 10.6023/cjoc202502005

Abstract( 187) HTML( 5) PDF(1303KB)( 96 )

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Nickel and Cobalt-Catalyzed Asymmetric Reductive Coupling of Halides with Aldehydes, Ketones and Imines

Jiangyan Tian, Chi Li, Jianfei Chen, Hui Lv

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 1946-1960 DOI: 10.6023/cjoc202412018

Abstract( 288) HTML( 11) PDF(1073KB)( 253 )

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Recent Advances in Asymmetric C—H Bond Functionalization Using Oxidizing Directing Groups

Shuang Wang, Yangjie Mao, Shaojie Lou, Danqian Xu

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 1961-1994 DOI: 10.6023/cjoc202409023

Abstract( 288) HTML( 10) PDF(1867KB)( 376 )

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Research Advances in the Synthetic Methodologies of N-Trifluoromethylamides

Tianxing Lin, Tianfei Liu

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 1995-2006 DOI: 10.6023/cjoc202409003

Abstract( 488) HTML( 7) PDF(837KB)( 365 )

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Recent Advances in Asymmetric Carbonylative Cross-Coupling Reactions

Lei Su, Xi Yang, Jie Yan, Yuanli Jiang, Lijuan Chen, Qingshu Zheng, Jiawang Liu

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2007-2047 DOI: 10.6023/cjoc202409024

Abstract( 316) HTML( 6) PDF(1711KB)( 283 )

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Progress in the Total Synthesis of Cephalotane Diterpenoid Natural Products

Yiming Ding, Tingrong Zhang, Jingwei Zhang, Jun Deng

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2048-2073 DOI: 10.6023/cjoc202408007

Abstract( 433) HTML( 7) PDF(1609KB)( 359 )

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Nucleophilic Aromatic Substitution Reactions via π-Coordination-Activation Transition Metals

Yixuan Ma, Kai Chen, Hang Shi

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2074-2085 DOI: 10.6023/cjoc202408036

Abstract( 476) HTML( 15) PDF(887KB)( 677 )

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Recent Advances in Photo-Induced Oxindole Formation from N-Arylacrylamides

Yongbo Tan, Hongbo Shu, Huawen Huang

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2086-2108 DOI: 10.6023/cjoc202407017

Abstract( 345) HTML( 4) PDF(1079KB)( 427 )

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ARTICLES

Rhodium(III)-Catalyzed Enantioselective Allylic C—H Alkylation of Unactivated Alkenes with α‑Diazocarbonyl Compounds

Qiang Zhou, Baozhen Yang, Guilin Hao, Mupeng Luo, Shi Cao, Bei Zhao, Hua Yuan, Shouguo Wang

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2109-2120 DOI: 10.6023/cjoc202505004

Abstract( 181) HTML( 10) PDF(728KB)( 124 )

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Ni-Catalyzed Reductive Alkylation of Polyfluoroarenes with Alkyl Halides

Shentong Xie, Wenjing Li, Yu Liu, Xi Lu, Renyi Shi

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2121-2127 DOI: 10.6023/cjoc202502007

Abstract( 205) HTML( 10) PDF(541KB)( 193 )

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Ag-Catalyzed Cyclization of Ugi-Azide Adducts for the Synthesis of Fully Substituted Fused Pyrroles

Shuzhen Luo, Quan Tang, Tianyu Long, Hao Wu, Han-Han Kong, Zhilin Ren, Qing-Qing Yang, Long Wang

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2128-2138 DOI: 10.6023/cjoc202502025

Abstract( 169) HTML( 6) PDF(633KB)( 106 )

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Phosphine-Catalyzed [2＋3] Annulation of Aurone-Derived Azadienes with Amino Crotonates

Gang Chen, Dong Chen, Guangjie Nie, Linxuan Li, Hui Yao, Nengzhong Wang, Nianyu Huang

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2139-2148 DOI: 10.6023/cjoc202501015

Abstract( 238) HTML( 9) PDF(909KB)( 118 )

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Iridium-Catalyzed Synthesis of Indole Derivatives from N-Aryl-2-aminopyridines and Vinylene Carbonate

Zhen Liang, Weiyan Xu, Yi Chen, Huayu Qiu, Yezhe Zhao, Jiabin Shen, Min Wang

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2149-2156 DOI: 10.6023/cjoc202411025

Abstract( 216) HTML( 3) PDF(571KB)( 88 )

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Iodine-Promoted Intermolecular Cyclization for the Synthesis of 2-Phenylquinazolines

Haojie Ma, Fengyuan Zhou, Yumeng He, Xiaoqiang Zhou, Zhou Sun, Yuqi Zhang

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2157-2162 DOI: 10.6023/cjoc202410019

Abstract( 214) HTML( 6) PDF(646KB)( 196 )

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Synthesis of α-Carbolinone Compounds Based on Tandem Cyclization Reaction of 2-Nitrochalcone and Ethyl Isocyanoacetate

Xinyao Sheng, Xinxin Li, Xiao Xing, Ling Pan, Qun Liu, Yifei Li

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2163-2170 DOI: 10.6023/cjoc202409014

Abstract( 199) HTML( 2) PDF(559KB)( 256 )

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HCF₂SO₂Na: a New Application as a Thioformylation Reagent for Amines

Chunyang Hu, Yasir Mumtaz, Khan Jahangir, Leibing Wang, Lvqi Jiang

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2171-2180 DOI: 10.6023/cjoc202409040

Abstract( 178) HTML( 0) PDF(580KB)( 160 )

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Copper/Selectfluor Co-catalyzed Ritter-Type Benzylic C—H Amination

Chunjie Qian, Boyang He, Xingyu Liu, Ping Wang, Guangchun Gao, Shihui Liu

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2181-2188 DOI: 10.6023/cjoc202409010

Abstract( 278) HTML( 13) PDF(597KB)( 250 )

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An Automatic Identification and Extraction Method for Organic Chemistry Literature Data Based on Language Expression Pattern and Natural Language Processing

Weiming Chen, Jingfang Dai, Yingyong Li, Junhong Zhou, Ben,Zhao,Yingli Gao, Tingjun Xu, Xiaosong Xue

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2189-2198 DOI: 10.6023/cjoc202409001

Abstract( 288) HTML( 10) PDF(8873KB)( 3894 )

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Study on Gold Self-Relay Catalytic Annulation/Nucleophilic Substitution of 1,3-Enyne Acetates with Cyclic Ether Acetals

Congyu Zhang, Xiaoqi Chen, Fantao Meng, Haiying Wang, Wen-Juan Hao, Bo Jiang

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2199-2207 DOI: 10.6023/cjoc202408027

Abstract( 374) HTML( 10) PDF(678KB)( 158 )

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Anthracene Photodimer-Derived Chiral Monophosphine Ligands: Preparative Route through Chemical Resolution and Synthetic Application in Asymmetric Allylic Amination

Tianlei Ren, Xin Wang, Huan Cong

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2208-2221 DOI: 10.6023/cjoc202409013

Abstract( 460) HTML( 9) PDF(986KB)( 326 )

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Transition-Metal Free Synthesis of Cyclopropanone Ketals via Double Defluorinative Alkoxylation of gem-Difluorinated Cyclopropanes

Lin Che, Zhong-Tao Jiang, Hui Yang, Fangdong Hu, Ying Xia

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2222-2230 DOI: 10.6023/cjoc202406020

Abstract( 409) HTML( 14) PDF(513KB)( 305 )

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Blue Light-Induced Formal Insertion Reaction of α-Siloxy Carbene into C—H Bond of 1,3-Diketones

Xinyu Jiang, Xinke Zhang, Xi Fang, Xinfang Xu

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2231-2238 DOI: 10.6023/cjoc202405026

Abstract( 248) HTML( 12) PDF(623KB)( 244 )

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HIGHLIGHTS

A Novel Radical Cyanodifluoromethylation Reagent BrCF₂CN

Fanjing Bu, Chao Liu

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2239-2242 DOI: 10.6023/cjoc202500014

Abstract( 83) HTML( 5) PDF(388KB)( 68 )

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Asymmetric Cross-Coupling of Epoxide Radical Anions Catalyzed by Copper Metal Photoredox

Zheng Liu, Huawen Huang

Chinese Journal of Organic Chemistry 2025, 45 (6), pp 2243-2244 DOI: 10.6023/cjoc202500015

Abstract( 126) HTML( 11) PDF(369KB)( 84 )

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